nursing reports journal

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2039-439X (Print)  / 2039-4403 (Online)

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Publisher MDPI AG , Switzerland Manuscripts accepted in English

LCC subjects Look up the Library of Congress Classification Outline Medicine: Nursing Keywords cancer nuring home care nursing practice nursing research nursing healthcare

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Introducing Nursing Reports: An Open Access Nursing Journal That's a Little Bit Different

Affiliation.

• 1 School of Nursing and Midwifery, La Trobe University, Melbourne, VIC 3083, Australia.
• PMID: 34968262
• PMCID: PMC8608093
• DOI: 10.3390/nursrep10010005

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Conflict of interest statement

The authors declare no conflict of interest.

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Nursing Research

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Journal logo, current issue.

September/October 2024 - Volume 73 - Issue 5

• Editor-in-Chief: Rita Pickler, PhD, RN, FAAN
• ISSN: 0029-6562
• Online ISSN: 1538-9847
• Frequency: 6 issues / year
• Impact Factor: 2.2 5-year Impact Factor 2.6

Featured Supplement

May/June 2024 - Volume 73 - Abstracts for the 2024 ENRS Annual Scientific Sessions​

Inane hall of fame.

​​​​​​​​​​​​​​The International Academy of Nursing Editors (INANE) has named Nursing Research to the inaugural class of the Nursing Journal Hal​​l of Fame . The award rec​​​ognizes scholarly nursing j​​​​ournals that have 50 or more years of contin​uous publication and sustained contributions to nursing knowledge. Nursing Research , founded in 1952, is the first nursing journal with an express mission to publish research. The award was presented at the INANE meeting in August 2018​​​​

Editorial Mission

​The editorial mission of Nursing Research is to report scientific research findings that advance understanding of all aspects of health. Research across the spectrum of biological, behavioral, psychosocial, spiritual, and cultural factors in health is published. Nursing intervention and outcome research as well as qualitative and mixed methods research are within the editorial focus of Nursing Research. Basic, translational, and clinical research is published. Research about nursing systems and nursing resource management is also published as is research describing new or advanced research methods, analytic strategies, and research protocols.

Nursing Research is a peer reviewed , double-blind journal.

Nursing Research has a long and distinguished record in the history of nursing science. Since its launch in 1952, Nursing Research has been a “cooperative venture” of scientists, professional organizations, publisher, editorial staff, and readers to circulate scientific papers in nursing to improve care, alleviate suffering, and advance well-being. Today, Nursing Research continues as a preeminent journal in the field, and is the official journal of the Eastern Nursing Research Society (ENRS) and the Western Institute of Nursing (WIN). 

Nursing Research publishes regular papers and brief reports in the following areas:

•  Research Reports  (Original, empirical research findings in areas of interest to nursing scientists) 

•  Reviews  (Reviews in biological sciences or symptom science)

•  Methods  (Development and application of new methods. Measurement, statistics, informatics and analytics, qualitative, and mixed methods approaches. May include secondary analysis of previously reported data to illustrate leading edge methods)

•  Brief Reports

• Commentaries

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Editor's Picks

Current issue highlights, peer reviewer contributions, challenges, and training.

Nursing Research. 73(5):337-338, September/October 2024.

• Permissions
• LETTERS TO THE EDITOR

Nursing Science: This I Believe

Nursing Research. 73(5):339, September/October 2024.

Balancing Nursing Science With Biobehavioral Approaches

Nursing Research. 73(5):340, September/October 2024.

Enhancing Understanding and Management of Obesity: Reflections on Behavioral Weight Loss and Food Cue Reactivity

Nursing Research. 73(5):341, September/October 2024.

• ORIGINAL ARTICLES

Influence of Preterm Birth and Environmental Context on Academic Performance and Neurodevelopmental Outcomes

Nursing Research. 73(5):342-353, September/October 2024.

• Abstract Abstract

Treatment Complications Associated With Hospital Admission in Oropharyngeal Cancer Patients

Nursing Research. 73(5):354-363, September/October 2024.

Symptoms and Health-Related Quality of Life Among Older Adults Living With HIV

Nursing Research. 73(5):364-372, September/October 2024.

Comparison of Weighting Methods to Understand Improved Outcomes Attributable to Public Health Nursing Interventions

Nursing Research. 73(5):390-398, September/October 2024.

• BRIEF REPORTS

Reliability and Validity of Measures Commonly Utilized to Assess Nurse Well-Being

Nursing Research. 73(5):399-405, September/October 2024.

The Arcus Experience: Bridging the Data Science Gap for Nurse Researchers

Nursing Research. 73(5):406-412, September/October 2024.

• REVIEWER LIST

2023 Reviewer List

Nursing Research. 73(5):413-414, September/October 2024.

• AVAILABLE ONLINE ONLY

Acute Care Use Among Patients With Multiple Chronic Conditions Receiving Care From Nurse Practitioner Practices in Health Professional Shortage Areas

Nursing Research. 73(5):E212-E220, September/October 2024.

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	Title	Type
1		journal	2.377 Q1	144	135	637	7834	5028	557	7.31	58.03	64.17
2		journal	1.705 Q1	54	47	330	2667	1629	322	4.55	56.74	43.99
3		journal	1.592 Q1	125	343	1336	12330	5835	1001	3.19	35.95	53.14
4		journal	1.273 Q1	49	51	201	2294	651	171	3.09	44.98	60.12
5		journal	1.235 Q1	124	668	1095	29461	5559	1003	4.26	44.10	70.88
6		journal	1.218 Q1	178	539	1128	24318	5016	1015	4.34	45.12	76.87
7		journal	1.186 Q1	166	259	1004	8559	3651	914	2.91	33.05	60.88
8		journal	1.165 Q1	64	115	216	4262	1005	201	4.35	37.06	69.29
9		journal	1.102 Q1	94	119	257	5069	1011	235	3.06	42.60	69.20
10		journal	1.091 Q1	101	278	1094	11402	4789	1053	4.14	41.01	71.60
11		journal	1.069 Q1	59	70	178	2595	681	156	3.50	37.07	72.97
12		journal	1.065 Q1	71	126	390	4217	1184	296	3.12	33.47	82.92
13		journal	1.039 Q1	51	43	193	2607	554	191	2.79	60.63	66.86
14		journal	0.953 Q1	37	76	229	3264	831	201	2.87	42.95	66.67
15		journal	0.921 Q1	64	125	441	4217	1369	416	3.19	33.74	81.35
16		journal	0.919 Q1	41	161	620	5809	1711	574	1.48	36.08	70.99
17		journal	0.895 Q1	10	19	56	1158	209	55	3.09	60.95	65.49
18		journal	0.894 Q1	54	480	743	21827	2751	743	3.47	45.47	64.28
19		journal	0.884 Q1	61	104	359	2921	1293	343	3.92	28.09	76.19
20		journal	0.869 Q1	62	265	642	11384	2408	585	3.42	42.96	72.76
21		journal	0.867 Q1	57	314	805	15571	2406	786	2.66	49.59	54.31
22		journal	0.866 Q1	47	53	140	965	345	133	2.85	18.21	67.00
23		journal	0.865 Q1	24	39	117	1479	331	107	3.37	37.92	75.00
24		journal	0.820 Q1	45	26	98	1423	336	97	3.66	54.73	57.89
25		journal	0.818 Q1	62	97	173	5606	510	148	2.97	57.79	78.78
26		journal	0.794 Q1	108	332	1039	7682	1893	753	1.65	23.14	60.97
27		journal	0.790 Q1	11	49	98	2853	325	95	3.17	58.22	73.64
28		journal	0.782 Q1	34	737	870	31462	2729	847	3.19	42.69	67.83
29		journal	0.774 Q1	47	71	119	2709	347	108	2.47	38.15	78.22
30		journal	0.774 Q1	52	26	417	972	1193	409	2.86	37.38	66.67
31		journal	0.766 Q1	65	61	269	2310	778	262	3.15	37.87	69.72
32		journal	0.765 Q1	61	292	453	6606	976	424	2.05	22.62	74.47
33		journal	0.746 Q1	104	70	227	2265	519	203	2.17	32.36	70.28
34		journal	0.741 Q1	40	32	124	1462	350	123	2.28	45.69	61.16
35		journal	0.738 Q1	25	45	124	1082	336	101	2.50	24.04	60.33
36		journal	0.734 Q1	64	128	280	5386	738	268	2.40	42.08	69.06
37		journal	0.729 Q1	72	134	390	4915	850	334	1.98	36.68	75.59
38		journal	0.712 Q1	97	75	247	3199	522	192	2.16	42.65	74.00
39		journal	0.688 Q1	59	66	286	1733	546	227	1.63	26.26	73.48
40		journal	0.688 Q1	57	74	339	3124	878	316	2.34	42.22	63.01
41		journal	0.682 Q1	52	389	779	15570	2352	763	2.92	40.03	48.83
42		journal	0.678 Q1	58	20	84	1349	222	81	2.46	67.45	39.13
43		journal	0.648 Q1	61	118	412	3939	884	393	1.94	33.38	74.85
44		journal	0.633 Q2	12	144	210	5918	532	202	2.65	41.10	62.25
45		journal	0.617 Q2	50	116	368	4735	820	351	2.22	40.82	65.64
46		journal	0.615 Q2	45	90	208	3400	444	186	1.81	37.78	79.30
47		journal	0.613 Q2	50	91	261	2495	527	213	2.02	27.42	57.24
48		journal	0.612 Q2	60	212	409	5957	793	335	1.60	28.10	66.56
49		journal	0.601 Q2	17	236	282	8762	682	273	2.24	37.13	53.89
50		journal	0.596 Q2	44	56	191	1800	466	172	2.31	32.14	62.81

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Today’s Nursing Shortage: Workforce Considerations

Overview and Summary: Today’s Nursing Shortage: Workforce Considerations

The 6 new articles in the new OJIN topic, Today’s Nursing Shortage: Workforce Considerations , present contemporary aspects of the nursing shortage and actual and potential factors of concern.

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Journal of Clinical Nursing & Reports

Aim & scope, author guidelines, editorial board, articles in press, current issue, about journal.

Journal of Clinical Nursing & Reports is a peer-reviewed, open-access journal published by MK Science Set Publishers. Journal of Clinical Nursing & Reports reclines in scrutinizing all possible dimensions of nursing care and practice including the development of the nursing process; the concept of nursing diagnosis and focused attention on the identification of the patient problems that nurses know and treat. The topics covered in the journal include nursing education, Community nursing, Healthcare systems, Healthcare Management, Public Health Nursing, Advanced Practice Nursing, Family Nursing, Critical Care Nursing including Surgery, Midwifery, and Obstetrical Nursing. Journal of Clinical Nursing & Reports accepts original research articles, review articles, case reports, mini-reviews, rapid communication, opinions, and editorials on all related to nursing and care. Journal of Clinical Nursing& Reports covers the following topics: Nursing Education, Cardiac Nursing, Clinical Nursing, Community Health Nursing, Critical Care Nursing, Gastroenterology Nursing, Geriatric Nursing, Health Care Systems, Health Informatics, Health Services, Healthcare Delivery System, Medical Practice, Medical-Surgical Nursing, Mental Health Nursing Midwifery, Nephro- Urology Nursing, Neurosciences Nursing, Nurse Practitioners, Nursing and Health Care, Nursing Education, Nursing Ethics, Nursing Informatics, Nursing Management, Nursing Research & Statistics, Nursing Science, Nursing Theories, DNA, RNA, Chromosomes, Heredity, Genealogy, Interaction of multiple genes, Genetic code, Pseudo gene, Gene expression, Recombination and linkage, Genetic mapping, Gene regulation, Genetic change, Population genetics, Conservation genetics, Phylogenomic, Phylogenetics, Cloning, Genetically modified organisms, Human genetics, Comparative genomics, Behavioural genetics, Medical genetics, Genome projects, Copy number variation, Genetic diversity, Transcriptional profiling, Genes in the pathology of human disease, Molecular analysis of simple and complex genetic traits, Cancer genetics, Epigenetics, Gene therapy, Developmental genetics, Regulation of gene expression, Strategies and technologies for extracting function from genomic data, Pharmacological genomics, Genome evolution, Genetic and functional analysis of animal models of disease or behaviours, Genetic polymorphisms of biologically important genes, Human genome analysis.. Etc..

Journal of Clinical Nursing & Reports is an open-access, peer-reviewed journal that considers articles on all aspects of nursing research, training, education and practice. Each issue examines current issues and trends in nursing practice, education, and research, offering progressive solutions to the challenges facing the profession. The journal's peer-reviewed articles report the latest developments in the management of acute and chronic disorders and provide practical advice on the care of older adults across the long-term continuum. It disseminates research findings of particular interest to practicing nurses, provides an international forum for discussion among clinical nurse researchers and by identifying practical applications of research, enhances practice. The development of clinical practice and the changing patterns of inter-professional working are also central to the Clinical Nursing & Reports scope of interest. Contributions are welcomed from other health professionals on issues that have a direct impact on nursing practice.

The Journal of Clinical Nursing & Reports aims to:

• Provide a leading platform for the dissemination of significant research findings, clinical studies, and innovations in nursing practice and education.
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Dramatic Increase in Hospital Infections with Resistant Microorganisms: Solutions are Available

Review article guggenbichler s, and guggenbichler jp*, activation in cancer survivorship in kenya: results of a cluster-randomized trial, research article nebert k mchidi*, john p oyore and gordon ogweno, volume-3 2024, environmental factors associated with diarrhoea among under-five children attending at muhimbili national hospital, tanzania, research article victor mathias* and asumin mkalagale, unveiling the silent struggle: exploring intimate partner violence among older african american women: a qualitative interpretive meta-synthesis (qims), research article jacqueline burse*, tracey marie mcelwee, elizabeth heldman and hannah bosmyer campbell, hemodynamic changes following regional anesthesia for foot surgeries: a comparative study between ankle block and unilateral subarachnoid block, research article bashir garba aljannare* and khalid abdullahi, experimental investigation on microstructure, mechanical behavior and tribological analysis of al2017/sic/tio₂ composed by double stir casting route, research article shlok agarwal, kaustubh kambiri* and roop lal, effectiveness analysis of clinical pharmacists-led medication therapy of refined management mode: antibiotics administration, research article yue li*, yue liu*, riran zhu, jianfeng ju, ying wang, chao huang, chuanjiang ma, jingyi wang, li guo, zhijie chu, xiaoqian liu# and qun liu#, nursing care for a patient on evac treatment after anastomotic leak. case report, case report tsanko yotsov, miroslava ilieva*, despina georgieva and greta koleva, adherence to clinic appointments and medication among patients accessing mental health clinics in lilongwe, malawi: a cross-sectional analytical study, research article paul mekani*, eltony mugomeri, calorine kathomi mbuba, and balwani chingatichifwe mbakaya, advancing musculoskeletal health: exploring innovations and insights in arthritis research, short communication ashish pandey, volume-3, issue-1, volume-2 2023, volume-2, issue-1, volume-2, issue-2, volume-2, issue-3, volume-2, issue-4, volume-1 2022, volume-1, issue-1, presentations.

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The Emergence of Mpox: Epidemiology and Current Therapeutic Options

Samriddhi ranjan.

1 College of Public Health, George Mason University, 4400 University Drive Fairfax, Fairfax, VA 22030 USA

Kanupriya Vashishth

2 Advance Cardiac Centre Department of Cardiology, PGIMER, Chandigarh, 160012 India

3 NGO Praeventio, Tartu, Estonia

Hardeep Singh Tuli

4 Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala, Haryana, 133207 India

Associated Data

This document includes citations for all the data that were analysed throughout the literature review.

The world recently witnessed the emergence of new epidemic outbreaks like COVID-19 and mpox. The 2022 outbreak of mpox amid COVID-19 presents an intricate situation and requires strategies to combat the status quo. Some of the challenges to controlling an epidemic include present knowledge of the disease, available treatment options, appropriate health infrastructures facilities, current scientific methods, operations concepts, availability of technical staff, financial funds, and lastly international policies to control an epidemic state. These insufficiencies often hinder the control of disease spread and jeopardize the health of countless people. Also, disease outbreaks often put a huge burden on the developing economies. These countries are the worst affected and are immensely dependent on assistance provided from the larger economies to control such outbreaks. The first case of mpox was reported in the 1970s and several outbreaks were detected thereafter in the endemic areas eventually leading to the recent outbreak. Approximately, more than 80,000 individuals were infected, and 110 countries were affected by this outbreak. Yet, no definite vaccines and drugs are available to date. The lack of human clinical trials affected thousands of individuals in availing definite disease management. This paper focuses on the epidemiology of mpox, scientific concepts, and treatment options including future treatment modalities for mpox.

Introduction

Amidst the COVID-19 pandemic, another public health concern emerged as a potential threat to afflict people globally, i.e. an abrupt increase in the incidence of mpox (monkeypox) cases. Indeed, starting from mid-May 2022, cases of human mpox have significantly risen in several non-endemic countries worldwide, leading to the declaration of the ongoing outbreak of mpox as a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) in July 2022 [ 1 , 2 ]. Mpox disease is caused by the mpox virus (MPXV), a double-stranded DNA virus from the Orthopoxvirus genus, belonging to the Poxviridae family [ 2 , 3 ]. The same genus includes the variola virus, a known causative agent of smallpox [ 2 ]. Genetically, MPXV is identified with two types of clads. Clad I, also known as Congo Basin clad, is mostly clustered in the Central-South Cameroon region till DRC. Infections from this clad are more severe with case fatality rates (CRF) > 10%. Clad II also referred to as West African clad, commonly distributed in western Cameroon to the Sierra Leon area, is further divided into sub-clad groups as IIa and IIb (also now referred to as clad III) having a CRF < 1% [ 4 , 5 ]. Overall reported human case fatality rates (CFRs) range between 3.6 and 10.6% in the endemic regions [ 2 ]. In the current 2022 outbreak, clad IIb was predominant [ 6 , 7 ]. To date, the exact animal reservoir for the mpox virus (MPXV) has remained unknown. However, few native African rodents (Gambian giant rats) and squirrels are suspected to be natural reservoirs of the virus. Common species which were frequently infected with MPXV are squirrels, Gambian giant rats, strip mice, dormice, and primates [ 8 ].

Emergence of Mpox

The first outbreak of mpox was reported in 1958 in a group of 10 captive monkeys at the Statens Seruminstitut, Copehengan, Denmark, and Centre d’Enseignement et de Recherches de Medecine aeronautique, Paris. No human infection was reported in individuals who were in close contact with infected monkeys. Subsequently, the mpox outbreak occurred for the first time in humans between 1970 to 1971 [ 9 ]. The first case was reported in a 9-month-old boy residing in a remote village of the Democratic Republic of Congo (DRC), admitted to a local hospital suspected of smallpox infection. Samples from infected individuals were sent to the WHO Smallpox Reference Center, Moscow, revealing mpox infections in virus isolates [ 10 ]. When inspected from family, monkeys were part of the diet, and their skins were also processed in this area. However, no other cases including secondary infections were reported in the community. Nonetheless, seven more cases were reported during this time period [ 9 ]. The World Health Organization in 1967 took the initiative to collaborate with laboratories to conduct cooperative studies. This was to conduct serological surveys, identify mpox outbreaks, and determine the natural foci of the virus. However, these surveys failed to state any major findings and concluded mpox is not a widespread disease and can exist only in the local environment [ 9 ]. Ever since, there has been a subsequent upsurge of mpox cases, mostly recorded in the DRC province. Approximately, 80% of the cases were reported in this region from the years 1970–1997 [ 11 ]. For the past five decades, DRC is the most affected country with mpox; no other country had reported an mpox outbreak to such an extent [ 12 ].

The initial mpox outbreak that was reported in DRC mostly affected children below 10 years of age. A slight male predominance was observed in the systemic review conducted by Beer and Rao [ 11 ]. Most of the initial outbreaks occurred among individuals living in small rural areas or residing close to humid evergreen tropical forests or individuals commonly involved with bushmeat hunting [ 11 ]. Geographically, the spread of infection from 1970 to 2003 concentrated in the Central and Western parts of Africa (Table 1). Countries which frequently reported infections were Cameroon, the Central African Republic, Gabon, Sierra Leone, Liberia, Nigeria, and Cote d’Ivoire, yet greater outbreaks were mostly detected in DRC [ 13 ]. An active surveillance programme was carried out by WHO between the years 1981 to 1986 reporting total confirmed cases of 338 and 33 deaths, an almost 20 times rise in the reported case after the surveillance [ 10 , 11 ]. A slight drop in the incidence of disease was observed between the period of 1993–1995. But soon after, DRC witnessed a major outbreak from 1996–1997 [ 13 ]. A total of 511 cases were recorded with a surge in secondary transmission rates of up to 78% and a fatality rate between 1 and 5% [ 10 , 13 ].

In 2003, the mpox outbreak occurred for the first time in the USA, outside the African continent. The index case was a 3-year-old girl, bitten by an infected prairie dog, imported from Ghana along with other African rodents to the USA [ 14 ]. A total of 71 cases were reported, including both suspected and laboratory-confirmed cases, as per the CDC report [ 15 ]. During the period of 2005, mpox was registered for the first time in the dry savannah region of Sudan. Overall, 40 cases both suspected and confirmed were recorded. In this outbreak, a change in the genomic structure of MPXV was observed as compared to the MPXV traditionally reported in DRC suggesting the adaptability of MPVX in dry regions from humid evergreen tropical forests [ 10 ]. In the year 2018, mpox travelled for the first time to the UK and was reported in the European continent. Only two cases were registered, in individuals, which had a travel history to Nigeria [ 16 ]. Nevertheless, with the advent of 2022, the world saw a major outbreak of mpox (Table ​ (Table1 1 ).

Decade-wise spread of mpox across different countries between 1970 and 2020 9,10

Mpox Outbreak 2022

Mpox is endemic in Central and West Africa, where hundreds of cases were detected annually for many years, acquired mostly from wild animals and most rarely from infected humans [ 1 , 3 ], which results in a sporadic spillover of cases in humans as observed in the MPVX endemic regions [ 5 ]. However, in the 2022 outbreak of mpox, most of the cases were reported in non-endemic countries like N. America, S. America, and Europe (Fig.  1 ) [ 17 ]. Although the origin of the 2022 outbreak is still unknown, it is highly likely that the initial infection has been imported from an endemic country, allowing the circulation of the virus through close physical contacts among humans [ 1 , 18 ]. For the first time, mpox was documented with transmission chains in countries which had no immediate contact with Central or Western Africa [ 19 , 20 ]. This suggests a probability of undetected MPXV circulating in the local population in the outbreak-hit regions causing disease transmission in humans [ 17 ]. Being a DNA virus, mpox is more stable in nature and may have possibly evolved as a potent virus causing infections in humans in the due course of time [ 17 ]. Daniel et al. reported 6–12 times higher mutation rates in mpox as previously estimated [ 6 ]. Human to human transmissibility of mpox has also evolved in these decades [ 21 , 22 ]. Vertical infection of mpox has been also reported. Pregnant mothers infected with mpox had miscarriages during the first trimester of pregnancy [ 6 ]. Perinatally acquired mpox infection was registered in a 9-day year old neonate as well [ 23 ]. Transmissibility of infection within the family especially from parents to children have also been stated to increase [ 20 , 22 ]. The degree of transmissibility of the diseases, popularly known as R 0 , reported in the 1980 for mpox was 0.83. However, in the 2022 outbreak, the R 0 reported was 1.1–2.4 [ 21 , 24 ]. Pan et al. suggested the increase in the R 0 is due to decreased immunity of individuals due to the absence of smallpox immunization and high contact rates of infection in the MSM community [ 6 ].

Countries reporting mpox historically vs countries reporting an mpox outbreak as recorded in an early March 2023 report by CDC 19

As per the WHO, till 17 March 2023, the total confirmed cases for mpox were 86,601, with 1265 probable cases reported with 112 deaths. Globally, 110 countries were affected by mpox so far (Fig.  2 ) [ 20 ]. Approximately 34.7% of cases were reported in America, the worst affected country [ 20 ]. Majority of the infection occurred through household contacts (43%) and by sexual encounters (43%) [ 20 , 22 ]. Commonly affected individuals were young males who were not vaccinated against smallpox and have had sex with men. There was a slight male predisposition, with the median age reported as 34 years (IQR: 29–41). Around, 98% of individuals who were infected were either gay or bisexual, among which 41% of the people were HIV infected [ 4 ].

Mpox number of cases and deaths recorded in early March 2023 across the continent as per the report by CDC 19

On 23 July 2022, mpox was declared a public health emergency by the Public Health Emergency of International Concern (PHEIC), depicting a risk of international spread, along with significant international coordination to control the disease [ 25 ].

Clinical presentation of this disease includes three distinct phases, i.e. incubation, prodrome, and rash [ 2 ]. The incubation period can last for 3 to 20 days with the median being 7 days followed by the prodrome phase that is characterized by lethargy, myalgia, headache, fever, and lymphadenopathy which may last up to 5 days (Fig.  3 ) [ 2 , 4 , 18 ]. Lymphadenopathy is one of the critical features of the progression of the disease and often reported before the development of skin lesions [ 18 ]. Fever is usually followed by multiple papular, ulcerative, and vesiculopustular skin lesions [ 4 ], which progress from macules to papules, vesicles, pustules, crusts, and lastly scab, presenting for up to 4 weeks [ 2 , 18 ]. In 95% of the cases, skin lesions appears [ 4 ]. Common anatomical sites for skin lesions were anogenital with approximately 73% of cases followed by trunk, arms or legs, face, and eventually palms and soles, only accounting for 10% of the cases. Lesions developed contain infectious virus particles, through which the infection can be transmitted directly with human contacts [ 2 ]. Secondary complications include pneumonia, encephalitis, keratitis, gastroenteritis, sepsis, and secondary bacterial infections, affecting mostly patients with a previous diagnosis of HIV infection [ 2 , 4 , 5 ].

Common features reported in mpox infection 4

Current Treatment Modalities and Prevention

The strategy for the prevention and treatment of mpox is very similar to the treatment of Orthomyxovirus infection [ 26 ]. The 2022 outbreak revealed the urgency to control the spread of mpox as it has caused a potential threat in many countries [ 27 ]. Presently, there is no definitive cure for mpox infection, mild symptoms are manageable, and further complications can be avoided in patients with mpox with the help of supportive care [ 28 , 29 ]. Studies have depicted that patients with mild symptoms recover without any treatment [ 30 – 32 ]. Treatment options available for smallpox are also effective in the treatment of mpox, as the clinical presentation of mpox and smallpox is very similar. These include the vaccinia vaccine, vaccinia immune globulin (IVG), and antiviral agents such as cidofovir, tecovirimat, and brincidofovir [ 32 ]. Furthermore, CDC recommends the use of the potential treatment options should be done depending upon the severity of the cases and for serious emergency cases, as the current drugs pose severe adverse effects, and their therapeutic efficacy is still uncertain [ 33 ]. Antiviral drugs are a choice of treatment in immunocompromised patients, in patients with complicated lesions, in pregnant women infected with mpox, in breast-feeding women, and in the paediatric population [ 34 ]. Tecovirimat is the first line of action antiviral recommended for the treatment of smallpox; it works by inhibiting the viral envelope protein, thereby blocking the final steps of virus maturation and release from infected cells, inhibiting the spread. As per the CDC guidelines, emergency access use of tecovirimat is allowed for compassionate use, for the treatment of Orthopoxvirus infections, such as mpox [ 35 , 36 ]. Cidofovir and its oral analogue brincidofovir are commonly approved drugs for the treatment of smallpox; both act by inhibiting viral DNA polymerase. Different studies have evaluated the effect of brincidofovir against Orthopoxvirus infections [ 37 ]. Studies done by Lanier et al. and others on the effect of cidofovir and brincidofovir have been evaluated for mpox with some success [ 34 , 37 ]. As per the recommended guidelines by CDC, preexposure smallpox vaccination has been advised for veterinarians, monkeypox contacts, healthcare workers caring for mpox patients, researchers, and field investigators [ 38 ]. Prior immunization with the smallpox vaccine has demonstrated some proven protective effects against mpox due to the cross-protective immunity provided by the smallpox vaccine. Furthermore, the severity of clinical manifestations is also reduced [ 39 ]. Currently, three available smallpox vaccines with the US national stockpile, i.e. JYNNEOSTM, ACAM2000, have been licenced (2007) for smallpox, the most recent being Aventis Pasteur Smallpox Vaccine (APSV) which could be potentially used for mpox on a case-to-case basis, under an investigational new drug (IND) protocol. JYNNEOSTM, a third-generation and live viral vaccine, is produced from the modified vaccinia Ankara-Bavarian Nordic [ 40 – 42 ]. Licenced in 2019, JYNNEOSTM is an attenuated non-replicating orthopoxvirus. It is now indicated for both smallpox and mpox prevention for adults. Further, ACAM2000, a second-generation vaccine constituted of live vaccinia virus, under the emergency access ACAM2000 is allowed for mpox during the outbreak. Researchers have demonstrated that these vaccines can be used as pre- and post-treatment options, i.e. either in preventing the infection and the disease or in ameliorating the infection and disease [ 34 , 43 , 44 ]. Studies have demonstrated that pregnant women, children less than 8 years of age, and immunocompromised patients should be given antiviral treatment than vaccination. These vaccines, although approved, have shown some local and systematic side effects such as fever, muscle pain, vaccinia, abdominal and back pain, fatigue, headache, lymphadenopathy, etc. [ 42 – 44 ]. Researchers have also highlighted the need for maintaining appropriate social barriers such as avoiding close contact with affected individuals, avoiding contact with skin lesions of individuals infected with MPXV, etc. [ 44 – 46 ]. Vaccinia immune globulin intravenous (VIGIV) is a choice of treatment in case of severe infection with mpox, though there is a paucity of data about its effectiveness in treating mpox. VIGIV is also under SNS and can be administered under investigational new drugs held by CDC [ 29 , 30 , 47 – 49 ]. Therefore, the treatment options and the repurposing of vaccines need to be considered on a case-to-case basis depending on the severity of cases and the immune state of patients [ 50 ] (Fig. ​ (Fig.4 4 ).

A Symptoms and B mechanism of action of mpox antiviral therapy: cidofovir, brincidofovir, vaccinia immune globulin, and tecovirimat [ 50 ] 

Key Fundamental Findings of the Narrative Review

Some major key findings related to mpox are as follows: mpox was solely endemic to the region of DRC [ 11 ]. There has been a slow and steady increase in mpox cases which has adapted itself to develop into the current outbreak. Secondly, the 1996–1997 DRC outbreak highlighted the increase in secondary transmission rates of mpox, potentially getting adapted to spread in the human population [ 13 ]. Thirdly, the MPXV had adapted to thrive itself from the humid evergreen regions to the dry savannah region of Sudan, as observed in the 2005 outbreak, thus further demonstrating its environmental adaptability to flourish [ 10 ]. Lastly, international travel and commerce have given a wider chance for the disease to spread as reported in the 2003 and 2018 outbreaks of mpox in the USA and the UK [ 14 , 16 ]. All these above factors have led to the 2022 outbreak of mpox, affecting every continent across the globe (Fig.  5 ).

Global spread of mpox in 2023 outbreak 19

Most of the consistent outbreak guidelines available from WHO or CDC only account for people with a high risk of exposure; these guidelines are based on the best available evidence which is based upon risk–benefit analysis and other factors [ 51 ]. Available drugs for the treatment of choice are also limited and lack evidence-based studies in humans [ 29 , 30 , 48 ]. This depicts an extensive need to increase the sustainable funding option to enhance our understanding of the development of new drugs and vaccines to curtail the spread of mpox.

Implication in Future Research

The environmental, behavioural, and social reasons behind the 2022 mpox outbreak remain unknown to date [ 1 ]. A deeper understanding of mpox genetics and biochemistry is essential to control its outbreak. It is currently unclear how mpox is closely related and linked to the viral strain that is primarily found in western Africa, as well as the potential routes of rapid transmission. To further understand the immune defence mechanisms against MPXV, more research is needed on the human systemic and mucosal immune responses. As DNA viruses are more adept to correct mutations; therefore, it is unlikely that the mpox virus will suddenly change during human transmission [ 24 , 52 ]. It is yet unknown, whether vaccinations and earlier infections have given the population immunity. Additionally, exploratory studies are required to pinpoint the precise mpox virus reservoir, understand how the virus spreads naturally, and determine the causes of the present increase in cases across several nations. Currently, no potent drugs are available and limited evidence-based studies are being conducted for the treatment of mpox [ 29 ]. Most of the available choices of treatment are discussed in this paper (Fig.  6 ). Therefore, it becomes essential to investigate the domain of natural products with antiviral properties. This provides alternative treatment options, to prevent human to human spread of infection and restrict virus amplification in the host organisms. There is a recent increased interest among the scientific community to look into the numerous bioactivities of structurally unrelated natural compounds [ 53 , 54 ]. Plant-derived polyphenol resveratrol has beeb shown to significantly suppress replication of MPXV affecting probably the viral DNA synthesis and inducing a comparable effect to the well-characterized Orthopoxvirus inhibitor, i.e. cytosine-1-β- d -arabinofuranoside (AraC) [ 55 ]. Due to the pleiotropic action of natural compounds and lack of systemic toxicity, plant-derived agents may represent target compounds to be explored in future clinical trials to enrich the drug arsenal against Orthopoxvirus infections. Parallel to this, early detection of infected patients who are potentially capable of transmitting the infection is also crucial, pointing to the need for improved diagnosis (particularly in atypical clinical presentations and asymptomatic cases), and better availability of molecular tests. Besides, such continual efforts of preclinical scientists and pharmaceutical companies, availability of health infrastructures, and medical staff are of critical importance—a situation still aggravated by the ongoing COVID-19 pandemic. A high-risk patient population is possibly in danger of mpox nosocomial transmission and deserves more attention. Therefore, it is crucial to administer the proper supportive care [ 24 ]. Consequently, it is necessary to improve genomic sequencing capabilities to identify the mpox viral clade(s). The primary necessities are to combat the spread of mpox while dealing with the ongoing COVID-19 pandemic and to include suitable and timely information campaigns for people at risk. It is challenging to create an evidence-based classification of drug safety and effectiveness having a brief history of mpox. Further studies on various animal models, which may affect medication exposure, are also encouraged. The focus of larger research should be on identifying the patients who are most at risk for consequences from mpox infection as well as the best timing for initiating and completing antiviral therapy.

Different treatment modalities in mpox

The emergence of new diseases is one of the incessant threats which mankind can face. Persistent interference between the environment and humans creates an opportunity for new infections to evolve. Over 75% of the pathogens, which are newly emerging, are zoonotic in nature [ 56 ]. Several diseases like HIV/AIDS, Nipah, SARS, and Ebola including mpox have recently appeared. International travel and commerce and human behaviour often help disease to spread [ 56 ]. With the first emergence of mpox in 1958, little is still known about its reservoir host and vector of the disease. Despite repeated outbreaks of mpox over the past years, it has failed to gather scientific attention. There is a lack of understanding of mpox transmission dynamics and disease evolution. In the areas endemic to mpox, regular disease surveillance is lacking. This also includes the need to promote funding for capacity building required for surveillance of the disease, research activities, and testing facilities [ 17 , 57 ]. The role of central bodies like the World Health Organization plays a major role in controlling such outbreaks. However, non-compliance to guidelines and regulations by health agencies like WHO severely impacts the control measures [ 25 ]. Boosting vaccine development and effective drug development is essential to prevent future outbreaks. In addition, new plant-derived products could be further developed and can be promoted as they potentially have lesser side effects for mpox treatment.

Abbreviations

Mpox	Monkeypox
MPXV	Mpox virus
PHEIC	Public Health Emergency of International Concern
DRC	Democratic Republic of Congo
SNS	Strategic National Stockpile
VIGIV	Vaccinia immune globulin intravenous

Author Contribution

SR, KV, and KS: conceptualization and writing; HST: editing and proofreading. All authors reviewed the manuscript.

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