powerpoint presentation on multiple sclerosis

Got any suggestions?

We want to hear from you! Send us a message and help improve Slidesgo

Top searches

Trending searches

thankgiving

5 templates

94 templates

11 templates

american history

85 templates

tropical island

31 templates

Multiple Sclerosis Disease

It seems that you like this template, multiple sclerosis disease presentation, free google slides theme, powerpoint template, and canva presentation template.

Download the Multiple Sclerosis Disease presentation for PowerPoint or Google Slides. Taking care of yourself and of those around you is key! By learning about various illnesses and how they are spread, people can get a better understanding of them and make informed decisions about eating, exercise, and seeking medical attention. This Google Slides theme and PowerPoint template is editable and can be used to teach the general public or medical students about a certain disease.

Features of this template

• 100% editable and easy to modify
• Different slides to impress your audience
• Contains easy-to-edit graphics such as graphs, maps, tables, timelines and mockups
• Includes 500+ icons and Flaticon’s extension for customizing your slides
• Designed to be used in Google Slides, Canva, and Microsoft PowerPoint
• Includes information about fonts, colors, and credits of the resources used

How can I use the template?

Am I free to use the templates?

How to attribute?

Attribution required If you are a free user, you must attribute Slidesgo by keeping the slide where the credits appear. How to attribute?

Register for free and start downloading now

Related posts on our blog.

How to Add, Duplicate, Move, Delete or Hide Slides in Google Slides

How to Change Layouts in PowerPoint

How to Change the Slide Size in Google Slides

Related presentations.

Premium template

Unlock this template and gain unlimited access

Multiple Sclerosis (MS)

Apr 26, 2012

850 likes | 2.38k Views

Multiple Sclerosis (MS). Dr Oliver Lily Consultant Neurologist Leeds General Infirmary. Multiple sclerosis. What is MS? What causes MS? Symptoms and signs of MS Making the diagnosis Investigations Treatments. Case Study: Ms A. 20 year old medical student

Share Presentation

• neurologist leeds general infirmary
• n engl j med
• dr oliver lily
• good prognosis
• vascular cell adhesion

Presentation Transcript

Multiple Sclerosis (MS) Dr Oliver Lily Consultant Neurologist Leeds General Infirmary

Multiple sclerosis • What is MS? • What causes MS? • Symptoms and signs of MS • Making the diagnosis • Investigations • Treatments

Case Study: Ms A • 20 year old medical student • Presented with 3 day history of pain in the left eye with blurred vision • On examination: • Reduced colour vision (Ishihara chart) • Reduced pupillary light responses (RAPD) • Hole in visual field (scotoma)

Case Study: Ms A • Next day, awoke to find vision completely gone in left eye! • Diagnosis?

Optic Neuritis • Inflammation of the optic nerve • Causes pain and loss of vision • Frequently not visible (retrobulbar) • Good prognosis: 95% return to visual acuity of 6/12 or greater within 12 months • High dose steroids speed up rate of recovery but have no effect on final acuity • 50% go on to develop MS within 10 years

Case Study: Ms A • Eye completely better within 3 months with no treatment. • Well for 2 years • Week of medical finals, complained of tingly numbness starting in both feet and gradually ascending to level around chest “like a tight band”. Felt unsteady walking and fatigued easily. • Electric shock sensations running down body whenever she bent her head • What is the diagnosis now?

Transverse myelitis • Inflammation inside the spinal chord • Often mild with good prognosis • Often pure sensory • Lhermittes phenomenon • May affect bladder • 50% go on to develop Multiple Sclerosis

Other causes of myelitis • Infective • Herpes Zoster • HTLV-1 • Lyme disease • Autoimmune • Lupus • Sjogrens syndrome • Neuromyelitis optica • Long spinal lesion (3 segments) • Anti-aquaporin antibodies

Diagnosing MS • Clinical diagnosis • Relies on dissemination in time and place • ? Is this MS

Clinically Definite MS Optic neuritis and transverse myelitis at different times Not definite MS Clinically isolated syndrome (CIS) Myelitis and optic neuritis at the same time Recurrent myelitis Recurrent or sequential optic neuritis Diagnosing MS

Supporting investigations

What is MS? • MS is the most common cause of neurological disability in young adults in the UK • 792 people with MS in Leeds • 40 new cases of MS / year

What is MS? • MS is a disease of the central nervous system (CNS) • An inflammatory reaction in the CNS causes loss of myelin and slowing of nerve conduction • Areas of demyelination • Loss of axons

Outcome: Ms A • Treated with intravenous methylprednisolone 1g daily for 3 days • Improved to normal over next 6 weeks • Told she had diagnosis of relapsing-remitting multiple sclerosis • Started on treatment with beta-interferon 1a injections • Remained in remission for next five years

Disease modifying treatments:Immunomodulation • Interferon beta 1-b • Interferon beta 1-a • Glatiramer acetate / Copaxone

Interferon beta • Reduces the number of relapses by 30% compared to placebo • Effective early in the disease course • No evidence on long-term effect on disability

Disease-modifying drugs

The case of Dr A • Now working as a GP • 34 years old • Noticing that when she walks, after a mile or so her left leg tingles and begins to drag. If she stops for a few minutes she can carry on normally. • Referred for physiotherapy • Returns two years later. Is limping on left leg and carries a walking stick. Right leg also feels stiff and wooden. Noticed urinary urgency and occasional spasms in the legs

Case of Dr A • On examination has weakness of flexors more than extensors worse on the left, with a left sided foot drop. There is increased tone and sustained clonus in both legs with very brisk reflexes and upgoing plantars. • Spastic paraparesis – suggests a spinal chord problem • ? diagnosis

Axonal loss in MS Disability Time

Axonal loss in MS Disability Axonal loss Inflammation Time

The case of Dr A • Over the next five years walking becomes more difficult and she has to start using two elbow crutches and then a wheelchair • Her interferon is stopped but she continues with regular physiotherapy • She gets more forgetful, and eventually retires from the health service aged 42 • 15% of MS patients are confined to a wheelchair within 10 years of diagnosis

Newer treatments for RRMS:the return of immunosuppression! • Mitoxantrone • Natalizumab • Oral Treatments (Fingolimod)

Edan G, et al.Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria. (n=42) Journal of Neurology, Neurosurgery and Psychiatry 1997;62:112-118.

Edan G, et al.Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria. (n=42) Journal of Neurology, Neurosurgery and Psychiatry 1997;62:112-118. Hartung H-P, et al.Mitoxantrone in progressive multiple sclerosis: a placebo controlled, double-blind, randomised, multicentre trial.(n=194) Lancet 2002;360:2018-2025.

Mitoxantrone • Rapidly progressive patients • Improvements in disability/mobility as well as relapse rates (up to 90%) • Prolonged improvement (up to 18m after treatment) • 1 in 300 chance of secondary leukaemia • Dose related cardiomyopathy

Mitoxantrone chemotherapy 35 responders 30 failures 25 20 Diseaseduration 15 10 5 0

Natalizumab (Tysabri) VCAM-1 = vascular cell adhesion molecule-1.Lobb RR et al. J Clin Invest. 1994;94:1722-1728.

1. Connell B et al. Ann Neurol. 1995;37:424-435. 2. von Adrian UH et al. N Engl J Med. 2003;34:68-72.

1. Cannella B et al. Ann Neurol. 1995;37:424-435. 2. von Andrian UH et al. N Engl J Med. 2003;348:68-72. 3. TYSABRI® (natalizumab) US Prescribing information, 2004.

Elan shares dive on drug setback Shares in Irish drugmaker Elan have plummeted once more after a third case of disease linked to Tysabri, its multiple sclerosis treatment. Elan suspended the drug after two patients were found to have caught the rare disease, one of whom later died. The newly revealed case - which also ended with the death of the patient - could mean Tysabri never makes it back onto the market, analysts warned. By the close of trading, Elan shares were down 56% to 2.43 euros. The initial cases had involved patients taking both Tysabri and US firm Biogen Idec's drug Avonex, and Elan had hoped that the problem was due to an unexpected problem with the combination. The latest, however, involves Tysabri alone. Biogen's shares were down 11% by 1600 GMT.

Tysabri • Rapidly evolving MS • Monthly infusions • 67% reduction in relapse rate • 95 cases PML worldwide (50 deaths) • Chance ranges from 1 in 10000 (JC seronegative 1st year) to 1 in 125 • Yearly MRI surveillance

Fingolimod (Gilenya) • Sphingosine-1-phosphate receptor blocker; traps lymphocytes in lymph nodes • Licenced for rapidly evolving MS (second line) • 60% reduction in relapse rate • Side effects include bradycardia, macula oedema, infections (esp herpes virus), skin cancers

Drugs/treatments for MS with no proven benefit over placebo • Naltrexone • Vitamin D, E, B12, fish oils • Special diets • Venous angioplasty/stenting • Stem cell treatments (other than bone marrow transplant) • Sativex

Sativex • 160 people with MS took part in this trial which compared the effects of Sativex versus placebo on spasticity, spasms, pain, bladder and tremor. No significant improvements were seen in overall symptom relief • 189 people with MS and spasticity symptoms took part in a study which compared the effects of Sativex versus placebo. Changes in spasticity during the six-week study were recorded using a patient-reported scale and a clinical measure of spasticity. Improvements were seen on the patient-reported scale but improvements seen on the clinical scale did not reach statistical significance.

Why do MS patients consult?

Why do MS patients consult? • Relapses: Least likely reason

• More by User

Multiple Sclerosis

Multiple Sclerosis. Charity, Scott, Natalia. Unless otherwise noted all information was obtained via National MS Society and National MS Society WA Chapter. Multiple Sclerosis Mystery. MS is thought to be an autoimmune disease Affects CNS

574 views • 14 slides

Multiple Sclerosis. CS295 Final Presentation Yongxing Guo Dec. 18, 2007. Outlines. Introduction to Multiple Sclerosis (MS) Genomewide Association Study of MS IL2RA & IL7RA and MS risk Comments. What’s Multiple Sclerosis (MS). First described by Charcot in 1868.

709 views • 19 slides

MULTIPLE SCLEROSIS (MS)

MULTIPLE SCLEROSIS (MS). CASE STUDY . 30 year old white female presents to family physician with acute loss of vision in left eye Referred to neurologist Diagnosis of optic neuritis Treated with IV corticosteroids for 5 days Normal vision over next 3 weeks Family history (mother)

1.77k views • 41 slides

MULTIPLE SCLEROSIS

MULTIPLE SCLEROSIS. BY EMILY HOWARD. Multiple Sclerosis (MS). Multiple sclerosis (or MS) is a chronic, often disabling disease of the immune system that attacks the central nervous system (CNS), which is made up of the brain, spinal cord, and optic nerves.

300 views • 13 slides

Multiple Sclerosis (MS). By: Morgan Farr Biology 1010. What is it?. Multiple sclerosis is an autoimmune disease that affects the brain and spinal cord (central nervous system).

361 views • 9 slides

University of Puerto Rico in Humacao. Multiple Sclerosis. And Controversies Around it. What is MS?. Multiple sclerosis (or MS) is a chronic, often disabling disease . Some of the Symptoms. Numbness Vision changes Pain. Different courses of MS. What causes MS. Genes Infections

347 views • 8 slides

Multiple Sclerosis (MS). LaTasha Wilson Nate Jr. Pathophysiology of MS. In MS, the body’s own defense system attacks myelin, the fatty substance that surrounds and protects the nerve fibers.

287 views • 11 slides

Multiple Sclerosis. By: Kaleb Wells And Joshua Turnbull. What is it?. MS is an auto immune disease which affects the central nervous system (CNS)

361 views • 7 slides

Multiple Sclerosis . Emily Toombs, Caroline Daughtry, Jaamal Davis . Description . About 4 out of 10 people with relapsing-remitting MS will progress to secondary progressive MS within 10 years. Pictures. Symptoms. Loss of balance Muscle spasms Strong urge to urinate Facial pain

264 views • 7 slides

Multiple Sclerosis. Presentation: Dallia Facts: Madison Visuals: Anastasia Veloudos. Degeneration of the nervous system is caused by an autoimmune response that destroys the nervous tissue due to multiple sclerosis (MS).

303 views • 7 slides

Multiple Sclerosis. Kristin Brown Mallory U’ren. What is MS. Multiple sclerosis (MS) is a disease in which the nerves of the central nervous system (brain and spinal cord) degenerate. Causes.

465 views • 16 slides

Multiple Sclerosis. Nanik “ Nayri ” Hatsakorzian Pharm.D /MPH Candidate 2014 Touro University – California College of Pharmacy . Overview. Pathophysiology Forms of MS Hallmark signs and symptoms Diagnosis Current treatments. Pathophysiology.

806 views • 27 slides

Multiple Sclerosis. Andrew Kemp Service Development Officer MS Society, South West. The MS Society. One aim: to beat MS 38,000 members 9,000 volunteers 260 staff members

784 views • 29 slides

MULTIPLE SCLEROSIS. Jack Ricciuti. EARLY SYMPTOMS. The most common early symptoms of MS include: Tingling Numbness Loss of balance Weakness in one or more limbs Blurred or double vision Less common symptoms of MS may include: Slurred speech Sudden onset of paralysis

200 views • 5 slides

Multiple Sclerosis (MS). Presented By: Alyssa Sturm & Brittany Gray December 4, 2012. What Are the Symptoms of MS?. Primary symptoms Loss of motor skills Loss of senses Physiological fatigue Speech problems Memory impairment Other symptoms depend on patient .

326 views • 16 slides

Multiple Sclerosis (MS )

Multiple Sclerosis (MS ). Dennis Garwacki, MD. Introduction to Multiple Sclerosis (MS). Chronic autoimmune disease Progressive disease Involves Immune System & Neurological System Multifocal areas of demyelination Disrupts ability of the nerve to conduct electrical impulses

857 views • 43 slides

Multiple Sclerosis. Abdulelah Nuqali Intern. What is Multiple Sclerosis?. Multiple Sclerosis (MS) is an acquired inflammatory demyelinating disease of the CNS (brain and spinal cord). How Common is MS and Who Gets It?. 8,000 – 10,000 new cases are diagnosed annually

691 views • 21 slides

Multiple Sclerosis. Presented by: Raul Salazar Jr. Felipe Ortiz Jr. What is MS ?. Multiple Sclerosis is one of the most common diseases of the CNS.

Multiple Sclerosis. How it affects us. Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). It is a disease of the white matter tissue.

440 views • 14 slides

Multiple Sclerosis. Abigail Lee. Rationale for Chosen Topic. Determining appropriate mobility assistive technology (MAT) for patients with physical disability due to Multiple Sclerosis (MS). Introduction. Purpose Statement

616 views • 12 slides

Multiple Sclerosis. Brett Glover Paramedic ’08 5/26/08. What is MS?. MS is a chronic, often disabling disease that attacks the CNS. MS is thought to be an autoimmune disease. T- cells attack myelin that protects nerve fibers. T-cells also secrete chemicals that damage nerve fibers

262 views • 18 slides

Multiple Sclerosis. By Kelsey Walker. Topics to Discuss…. Definition of MS Statistics Types of MS Being Diagnosed with MS Signs & Symptoms Treatment Options Scientific Progression Living with MS. ~Multiple Sclerosis~.

950 views • 47 slides