pharmacology research topics

Pharmacological Research

About the journal, aims & scope.

Bridging across disciplines

An IUPHAR-affiliated journal, International Union of Basic and Clinical Pharmacology

Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. We provide a venue through which specialists across disciplines can rapidly exchange information in health sciences that pertains to modern pharmacological topics. The journal publishes articles on molecular, biochemical, translational, and clinical research (including clinical trials); it is proud of its rapid publication of accepted papers that comprises a dedicated, fast acceptance and publication track for high profile articles.

Invited and unsolicited review articles are welcome.

Journal Sections

Specific sections are dedicated to:

The cardiovascular system:

CV disease therapy;

Signal transduction and receptor pharmacology in the CV system;

Target organs;

Clinical trials.

Neuroscience, including psychopharmacology, and neuroendocrinology:

Understanding of the central nervous system in physiological and pathological conditions;

Neuropharmacological and molecular mechanisms of learning and memory;

Therapeutic and diagnostic challenges for mental illness and neurodegerative diseases;

System biology.

Targeted cancer therapy;

Precision medicine and personalized therapy;

Signal transduction studies, as related to drug action;

Immunology (clinical and basic):

Immune and inflammatory mechanisms including target identification;

Immunotherapy and immunotoxicology;

Immunopathology;

Vaccines and adjuvants;

Treatment of infectious diseases.

Redox regulators and biological gases in pathophysiology:

Oxidative and nitrative stress and cell dysfunction;

Redox regulation of signal transduction in various diseases;

Pathophysiological roles of NO, CO and H2S;

Interaction between oxidants and gaseous mediators in health and disease;

Pharmacological modulators of oxidants, free radicals and gaseous transmitters.

Renal Pathophysiology and Pharmacology:

Acute and chronic kidney injury disease;

Metabolic alkalosis and metabolic acidosis in renal disease;

Renal excretion in electrolyte disorders;

Diabetes insipidus, Diabetic nephropathy;

Pathogenesis of glomerular disease;

End stage renal disease;

Prevention and treatment of nephrotic diseases.

Pregnancy Related Pharmacology and Perinatal Therapeutics:

Drug effects on the mother and foetus before and after birth;

Placental barrier and its relationship with drugs (transportation metabolism and so on);

Molecular signalling in placenta and identification of mechanisms beyond drug action in pregnancy;

Adverse effects of drugs drug/combination in placenta;

Drug repurposing/reprogramming for placenta-related disorders;

Regulatory aspects beyond clinical research in pregnant mothers;

Placenta remodelling in disease;

In vivo models of the diseased placenta;

The microbioma;

Effects of the environment on pregnancy;

Preventive vs therapeutic use of drugs.

Pharmacogenomics, Pharmacogenetics and Precision Medicine:

We are especially interested in GWAS studies and studies reporting pharmacogenetic data that are relevant in terms of safety and efficacy of drugs. They must provide insight into novel genomic or therapeutic associations that can help guide therapy selection or suggest new indications for established drugs. Studies can also provide details of exceptional responses in limited numbers of patients.

We also publish n=1 studies of exceptional responses, provided they are backed up by compelling genomic or experimental data.

Studies must include full clinical description of the case, along with details of the response and supporting molecular information. The molecular information should support the clinical observations and offer a definitive pharmacogenomic insight. Standard clinical sequencing assays (Foundation ONE, Genoptix etc) are only appropriate when the therapeutic or phenotypic response is novel. Ideally, the observational patient studies should be supported by lab based functional data.

Bioactive molecules derived from medicinal plants or natural products:

New, effective bioactive molecules;

Drug target identification;

Treatment mechanism;

Mechanism investigation with -omics and computational technologies;

Combinational therapy with natural products;

Multi-targeting and network pharmacology;

Herbal bioinformatics;

Precision medicine of natural products;

Evidenced-based research and clinical trials.

Studies reporting on plant extracts in which the active principle(s) has not been defined do not fall into the scope of this journal. Exceptions can be made for papers addressing the mechanisms of actions or the clinical applications of standardized herbal preparations. Clinical studies on commercially-available nutraceuticals are also taken into consideration.

Rare diseases and orphan drugs, and drug repositioning

We also publish articles focusing on:

Gastrointestinal and urogenital apparatuses when involving pharmacological issues ;

Pharmacology of tissue repair/regeneration ;

Pharmacology of aging ;

Nutraceuticals (if relevant to human disease) ;

Pharmacoeconomy ;

Pharmacoepidemiology .

We do not publish:

Papers reporting pharmacological activities of novel compounds if no proper controls with known substancesare performed;

Bioequivalence studies or studies reporting only the pharmacokinetics profile of a compound;

Descriptive pharmacovigilance studies;

Single dose/concentration studies and those measuring only one endpoint.

Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. We provide a venue through …

Article publishing charge for open access

Editor-in-Chief

Emilio Clementi, M.Mus, MD, PhD

University of Milan, Milano, Italy

Latest published

Articles in press, most downloaded, most popular, molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease, extracellular vesicles in the hcc microenvironment: implications for therapy and biomarkers, trp channels in cancer: therapeutic opportunities and research strategies, recent developments of topoisomerase inhibitors: clinical trials, emerging indications, novel molecules and global sales, targeting leptin/ccl3-ccl4 axes in nafld/mafld: a novel role for bpf in counteracting thalamic inflammation and white matter degeneration, orosomucoid 2 is an endogenous regulator of neuronal mitochondrial biogenesis and promotes functional recovery post-stroke, online ligand screening for cytochrome c from herbal medicines through “four-in-one” measurement, palmatine protects against atherosclerosis by gut microbiota and phenylalanine metabolism, more from pharmacological research, announcements, call for papers, meet our editors and board members, writing it right for pharmacological research, traditional chinese medicine news, calls for papers, current pharmacological challenges of treatment-resistant depression, advancing immunotherapy: unveiling biomarkers and mechanisms in the tumor-immune nexus, ion channels in immunity and inflammation, special issues and article collections, country in focus: pharmacology in spain, molecular mechanisms underlying the transition from acute to chronic pain, metabolic interactions of host-gut microbiota: shaping the future precision diagnosis and therapeutic discovery of gastrointestinal cancers, new strategies for medications to treat substance use disorders, partner journals.

Pharmacological Research - Modern Chinese Medicine

1.6 CiteScore

Pharmacy and Clinical Pharmacology

Explore JAMA Network Open’s collection on clinical pharmacy and pharmacology, including topics in drug safety and development, pharmacogenetics, and more.

Publication

Article type.

This cohort study examines whether treatment with nirmatrelvir and remdesivir is associated with emergent antiviral resistance in SARS-CoV-2 strains.

SARS-CoV-2 Nirmatrelvir Resistance—A Concern for Immunocompromised Populations? JAMA Network Open Opinion September 25, 2024 Clinical Pharmacy and Pharmacology Infectious Diseases Antibiotic Use, Overuse, Resistance, Stewardship Coronavirus (COVID-19) Full Text | pdf link PDF open access
The Promise and Perils of Oncology Care in Medicare Advantage JAMA Network Open Opinion September 20, 2024 Oncology Health Care Quality Pharmacoeconomics Health Policy Clinical Pharmacy and Pharmacology Full Text | pdf link PDF open access

This cohort study examines whether there are differences in resource use or care quality between patients with cancer undergoing chemotherapy who are enrolled in Medicare Advantage vs traditional Medicare.

This cohort study examines the association of seasonal influenza vaccination across successive pregnancies with adverse perinatal outcomes and whether the association varies by interpregnancy interval and vaccine type.

This systematic review evaluates the efficacy and safety of long-term use of skeletal muscle relaxants for low back pain, fibromyalgia, headaches, painful cramps or spasticity, and other syndromes.

This randomized clinical trial investigates whether early application of mycophenolate mofetil improves long-term outcomes in patients with newly diagnosed systemic lupus erythematosus with a high titer of anti–double-stranded DNA antibody and without major organ involvement.

This cohort study examines weight outcomes at 1 year in patients with obesity who received injectable forms of liraglutide or semaglutide compared by agent, indication, dosage, and persistent coverage with the medication.

This cross-sectional study describes national and regional Medicare spending and out-of-pocket costs for tafamidis from its approval in 2019 to 2021.

Tafamidis and the Paradox of Rare Disease Therapies JAMA Network Open Opinion September 13, 2024 Cardiology Clinical Pharmacy and Pharmacology Regulatory Agencies Pharmacoeconomics Health Policy Full Text | pdf link PDF open access

This cohort study evaluates whether there is a difference in kidney recovery outcomes following angiotensin receptor-neprilysin inhibitor (ARNI) vs angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) therapy among patients with malignant hypertension–associated thrombotic microangiopathy.

This cross-sectional study examines the association of Alzheimer disease and related dementias with prescription drug expenditures across cost distributions.

Reflections on Neonatal Erythropoietin Neuroprotection Studies JAMA Network Open Opinion September 10, 2024 Child Development Hematology Pediatrics Clinical Pharmacy and Pharmacology Neonatology Full Text | pdf link PDF open access

This cohort study examines whether early high-dose recombinant human erythropoietin is associated with better executive functions and processing speed among school-aged children who were born very preterm.

Managing Drug-Drug Interactions—So Many Drugs, So Little Evidence JAMA Network Open Opinion September 6, 2024 Clinical Pharmacy and Pharmacology Rheumatology Adverse Drug Events Coronavirus (COVID-19) Full Text | pdf link PDF open access

This randomized clinical trial evaluates the efficacy and safety of dual antiplatelet therapy with clopidogrel and aspirin compared with aspirin alone among patients in China with mild ischemic stroke or transient ischemic attack when initiated up to 72 hours after symptom onset.

This secondary analysis of a randomized clinical trial examines gastrointestinal adverse events due to interactions between colchicine and other medications in individuals with COVID-19.

This cross-sectional study investigates the association of medical and recreational legalization of cannabis and dispensary openings with the dispensing of psychotropic medications used to treat mental health disorders in the US.

Skepticism Calibration Disorder—The New Public Health Crisis JAMA Network Open Opinion September 4, 2024 Health Policy Nutrition, Obesity, Exercise Complementary and Alternative Medicine Clinical Pharmacy and Pharmacology Infectious Diseases Full Text | pdf link PDF open access

This survey study examines responses from community members and pharmacists for a potential bias in intuitive reasoning (post hoc bias) when asked for recommendations regarding a hypothetical scenario describing a patient who experiences marginal improvement in symptoms after a dubious treatment.

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Clinical Pharmacology: Current Topics and Case Studies

© 2016
Latest edition
Markus Müller 0

Universitätsklinik für Klinische, Medizinische Universität Wien, Wien, Austria

You can also search for this editor in PubMed Google Scholar

Updated and revised 2nd edition
Summarizes the latest topics, tools and clinical trials in clinical pharmacology
Added value for employees in drug research and development

61k Accesses

13 Citations

7 Altmetric

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About this book

Clinical Pharmacology Regulatory Sciences in Drug Development and Precision Medicine: Current Status and Emerging Trends

Clinical Drug Trials: The Path to the Patient

Clinical Research in Pharmaceutical Drug Development

drug development
clinical trial
gene therapy
pharmacodynamics
drug research
pharmacotherapy

Table of contents (23 chapters)

Front matter, introduction, the discipline of clinical pharmacology.

Markus Müller

Current Issues in Drug Development

Current issues in drug regulation.

Christa Wirthumer-Hoche, Brigitte Bloechl-Daum

Current Topics in Drug Reimbursement

Anna Bucsics, Robert Sauermann, Valerie Nell-Duxneuner

Clinical Trials

Ethics in clinical research.

Ernst Singer, Christiane Druml

Good Clinical Practice (GCP) and Scientific Misconduct

Brigitte Bloechl-Daum

Phase I Studies and First-In-Human Trials

Ulla Derhaschnig, Bernd Jilma

Clinical Trials: Interventional Studies

Michael Wolzt, Stefan Aschauer

Observational Studies

Harald Herkner, Christoph Male

Tools in Clinical Pharmacology

Tools in clinical pharmacology: imaging techniques.

Martin Bauer, Oliver Langer

Pharmacokinetics II: 14C-Labelled Microdosing in Assessing Drug Pharmacokinetics at Phase 0

Graham Lappin

Current Concepts of Pharmacogenetics, Pharmacogenomics, and the “Druggable” Genome

Wolfgang M. Schmidt, Robert M. Mader

Pharmacokinetics I: PK-PD Approach, the Case of Antibiotic Drug Development

Sherwin K. B. Sy, Hartmut Derendorf

Epidemiology and Biostatistics

Gerhard Garhöfer, Leopold Schmetterer

Placebo Effects and Placebo Control in Clinical Trials

Johannes Pleiner-Duxneuner

Topics in Clinical Pharmacology

“The aim is to describe the role of the discipline of clinical pharmacology in drug discovery. … The intended audience is faculty, researchers, and advanced students from academia and the pharmaceutical industry who are learning about or involved in the process of drug discovery. … This book provides a multitude of very useful insights about the successes and failures in drug development for scientists who are, or will be, involved in the process of drug discovery.” (Thomas L. Pazdernik, Doody's Book Reviews, May, 2016)

Editors and Affiliations

About the editor, bibliographic information.

Book Title : Clinical Pharmacology: Current Topics and Case Studies

Editors : Markus Müller

DOI : https://doi.org/10.1007/978-3-319-27347-1

Publisher : Springer Cham

eBook Packages : Biomedical and Life Sciences , Biomedical and Life Sciences (R0)

Hardcover ISBN : 978-3-319-27345-7 Published: 25 March 2016

Softcover ISBN : 978-3-319-80118-6 Published: 25 April 2018

eBook ISBN : 978-3-319-27347-1 Published: 15 March 2016

Edition Number : 2

Number of Pages : VI, 405

Number of Illustrations : 14 b/w illustrations, 16 illustrations in colour

Topics : Pharmacology/Toxicology , Pharmacy , Pharmacotherapy

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Clinical pharmacology: Current innovations and future challenges

Affiliations.

1 INSERM U1042, Université Grenoble Alpes, Grenoble, France.
2 CHU de Grenoble, Service de Pharmacologie - Pharmacosurveillance, CIC1406, Centre Régional de Pharmacovigilance, Grenoble, France.
3 INSERM, PARCC, Université de Paris, Paris, France.
4 CIC1418 and DMU CARTE, AP-HP, Hôpital Européen Georges-Pompidou, Paris, France.
5 Saint-Etienne, UMR1059, Université Jean-Monnet, Saint-Etienne, France.
6 CHU de Saint-Etienne, Unité de recherche clinique, Innovation et pharmacologie, Saint-Etienne, France.
7 Theranexus, Lyon, France.
8 Inserm, CHU Lille, U1172 - Degenerative & vascular cognitive disorders, Université Lille, Lille, France.
9 Inserm, CHU Lille, Clinical Investigation Center - CIC 1403, Université Lille, Lille, France.
10 CIC1401, INSERM U1045, University of Bordeaux, Bordeaux, France.
11 CHU de Bordeaux, CIC1401, Service de Pharmacologie Médicale, Bordeaux, France.
PMID: 34954839
DOI: 10.1111/fcp.12747

Clinical pharmacology is the study of drugs in humans, from first-in-human studies to randomized controlled trials (RCTs) and benefit-risk ratio assessment in large populations. The objective of this review is to present the recent innovations that may revolutionize the development of drugs in the future. On behalf of the French Society of Pharmacology and Therapeutics, we provide recommendations to address those future challenges in clinical pharmacology. Whatever the future will be, robust preliminary data on drug mechanism of action and rigorous study design will remain crucial prior to the start of pharmacological studies in human. At the present time, RCTs remain the gold standard to evaluate the efficacy of human drugs, although alternative designs (pragmatic trials, platform trials, etc.) are emerging. Innovations in healthy volunteers' studies and the contribution of new technologies such as artificial intelligence, machine learning, and internet-based trials have the potential to improve drug development. In the field of precision medicine, new disease phenotypes and endotypes will probably help to identify new pharmacological targets, responders to therapies, and patients at risk for drug adverse events. In such a moving landscape, the development of translational research through academic and private partnership, transparent sharing of clinical trial data and enhanced interactions between drug experts, patients, and the general public are priority areas for action.

Keywords: connected devices; drugs; machine learning; precision medicine; translational research; trials.

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Pharmaceutics articles from across Nature Portfolio

Pharmaceutics is the scientific discipline concerned with the process of creating the dosage form (such as a pill for oral administration or a powder for intravenous injection) of a therapeutic that is to be used by patients. It encompasses drug formulation and manufacturing.

Latest Research and Reviews

Exploring the unexplored: identifying knowledge gaps in novel pharmacological treatments for diabetic retinopathy

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Comparison of various chitosan-based in situ forming gels with sodium fluoride varnish for enamel biomineralization: an in-vitro pH cycling model

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Enabling target-aware molecule generation to follow multi objectives with Pareto MCTS

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News and Comment

Stopping the bleed when platelets don’t stick.

Defects in platelet adhesion at sites of injury can lead to excessive bleeding. A study by Gandhi et al. investigates a new bispecific antibody as a possible therapy to prevent bleeding in patients with inherited defects in platelet adhesion.

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Fast, instrument-free and low-cost selection of high-affinity aptamers

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Pharmacology Research Paper Topics

In this page on pharmacology research paper topics , we explore the diverse and dynamic field of pharmacology and provide valuable resources for students who are tasked with writing research papers in this discipline. Pharmacology, as a branch of science, encompasses the study of how drugs interact with biological systems, aiming to understand their mechanisms of action, therapeutic uses, and potential side effects. With the growing importance of pharmacology in healthcare and drug development, it is crucial for students to delve into relevant pharmacology research paper topics that contribute to advancing knowledge and addressing current challenges in the field. Additionally, we highlight iResearchNet’s writing services, offering students the opportunity to order custom pharmacology research papers tailored to their specific needs. Our team of expert writers, equipped with in-depth knowledge of pharmacology and related fields, ensures high-quality, well-researched papers that adhere to the highest academic standards.

In the field of pharmacology, research plays a critical role in advancing our understanding of drugs, their mechanisms of action, and their impact on human health. As students of pharmacology, you may be tasked with writing research papers that explore various aspects of this dynamic discipline. To assist you in your research journey, we have curated a comprehensive list of pharmacology research paper topics that cover a wide range of subfields and emerging areas of interest. Whether you are interested in drug discovery, clinical pharmacology, pharmacogenomics, or drug safety, this list provides a wealth of ideas to inspire and guide your research endeavors.

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Drug Discovery and Development

Role of Artificial Intelligence in Drug Discovery
Personalized Medicine: Tailoring Drug Therapy to Individual Patients
Drug Repurposing: Exploring New Indications for Existing Drugs
Pharmacogenomics and Drug Response Prediction
Nanomedicine: Applications in Drug Delivery and Targeting
Innovative Approaches for Drug Formulation and Delivery
Drug Combinations: Synergistic Effects and Therapeutic Opportunities
Natural Products as Sources of Novel Therapeutic Agents
Virtual Screening and Molecular Docking in Drug Design
Pharmacokinetics and Pharmacodynamics of New Drug Entities

Clinical Pharmacology

Precision Dosing: Optimizing Drug Therapy for Individual Patients
Pharmacokinetic Variability in Special Populations (Pediatrics, Geriatrics, Pregnant Women)
Drug-Drug Interactions: Mechanisms and Clinical Implications
Adverse Drug Reactions: Identification, Prevention, and Management
Pharmacovigilance and Drug Safety Monitoring
Therapeutic Drug Monitoring: Rationale and Practical Considerations
Clinical Trials in Pharmacology: Design, Implementation, and Analysis
Drug Development and Regulatory Approval Processes
Pharmacoeconomics: Evaluating the Cost-Effectiveness of Drug Therapy
Ethical Considerations in Clinical Pharmacology Research

Neuropharmacology and Psychopharmacology

Mechanisms of Action and Therapeutic Applications of Antidepressant Drugs
Neurotransmitter Systems and Their Role in Mental Health Disorders
Psychotropic Drugs and Their Impact on Cognitive Functioning
Novel Approaches for Targeting Neurodegenerative Disorders
Pharmacological Management of Substance Use Disorders
Pharmacogenetics in Psychiatry: Implications for Individualized Treatment
Role of Neuroinflammation in Neurological and Psychiatric Disorders
Neuropharmacology of Sleep and Wakefulness
Pharmacotherapy for Schizophrenia: Current Trends and Future Directions
Novel Treatments for Anxiety and Mood Disorders

Pharmacokinetics and Drug Metabolism

Drug Transporters and Their Role in Drug Disposition
Pharmacogenetics and Personalized Drug Therapy
Pharmacokinetic Variability and Its Impact on Drug Response
Drug Metabolism Pathways and Enzyme Polymorphisms
Drug-Drug Interactions: Mechanisms and Clinical Significance
Predictive Modeling in Pharmacokinetics and Dose Optimization
Pharmacokinetics in Special Populations: Pediatrics and Geriatrics
Impact of Genetic Variation on Drug Clearance and Toxicity
Role of Pharmacokinetics in Individualizing Drug Dosage
Strategies for Improving Oral Bioavailability of Drugs

Pharmacology of Infectious Diseases

Antimicrobial Resistance: Mechanisms, Epidemiology, and Strategies
Development of Novel Antiviral Agents: Challenges and Opportunities
Pharmacotherapy for Bacterial Infections: Current Approaches and Future Directions
Antifungal Drugs: Mechanisms of Action and Resistance
Host-Pathogen Interactions and Their Implications for Drug Development
Pharmacokinetic Considerations in the Treatment of Viral Infections
Targeting Virulence Factors in Bacterial Pathogens
Drug Combination Therapy for Multidrug-Resistant Infections
Pharmacogenomics of Antimicrobial Agents
New Approaches for Antiparasitic Drug Development

Cardiovascular Pharmacology

Novel Antiplatelet Agents: Mechanisms and Clinical Applications
Antihypertensive Therapy: Current Strategies and Future Perspectives
Pharmacotherapy for Heart Failure: Advancements and Challenges
Role of Pharmacogenomics in Cardiovascular Drug Therapy
Therapeutic Potential of Antiarrhythmic Agents
Pharmacological Management of Dyslipidemia and Atherosclerosis
Emerging Therapies for Pulmonary Hypertension
Pharmacological Approaches to Preventing Thromboembolic Disorders
Cardiotoxicity of Chemotherapeutic Agents: Mechanisms and Cardioprotective Strategies
Targeting Inflammatory Pathways in Cardiovascular Disease

Pharmacology and Aging

Geriatric Pharmacotherapy: Challenges and Approaches
Age-Related Changes in Pharmacokinetics and Pharmacodynamics
Polypharmacy and Its Impact on Older Adults
Adverse Drug Reactions in the Elderly: Recognition and Prevention
Pharmacological Management of Age-Related Neurodegenerative Disorders
Geriatric Pharmacogenomics: Implications for Personalized Medicine
Drug-Related Falls and Fractures in the Elderly: Prevention and Intervention
Medication Adherence in Older Adults: Barriers and Strategies
Geriatric Pain Management: Balancing Efficacy and Safety
Optimizing Drug Therapy in Older Adults with Multiple Comorbidities

Pharmacology of Cancer

Targeted Therapies for Solid Tumors: Recent Advances and Future Directions
Immunotherapy in Cancer Treatment: Current Approaches and Challenges
Pharmacogenomics of Chemotherapy: Implications for Personalized Treatment
Drug Resistance in Cancer: Mechanisms and Strategies for Overcoming Resistance
Pharmacokinetics and Pharmacodynamics of Anticancer Agents
Combination Therapies in Oncology: Rationale and Clinical Outcomes
Oncolytic Viruses: Exploiting Viral Infections for Cancer Treatment
Cancer Stem Cells: Targeting Tumor Initiation and Progression
Development of Novel Imaging Agents for Cancer Diagnosis and Monitoring
Pharmacological Interventions for Cancer-Associated Pain Management

Pharmacology and Immunology

Immune Checkpoint Inhibitors in Cancer Immunotherapy
Autoimmune Diseases: Novel Pharmacological Approaches and Therapies
Immunomodulatory Effects of Drugs: Implications for Therapeutic Interventions
Role of Pharmacogenomics in Immunomodulatory Drug Therapy
Immunopharmacology of Allergic Reactions: Mechanisms and Treatment Strategies
Immunosuppressive Drugs in Transplantation: Balancing Efficacy and Safety
Targeting Inflammatory Pathways in Autoimmune Disorders
Immunopharmacological Interventions for Infectious Diseases
Pharmacological Modulation of Cytokines in Inflammatory Disorders
Vaccines: Advancements in Development and Delivery

Pharmacovigilance and Drug Safety

Post-Marketing Surveillance: Detecting and Evaluating Adverse Drug Reactions
Signal Detection in Pharmacovigilance: Methods and Applications
Risk Management Strategies in Drug Development and Marketing
Pharmacogenomic Biomarkers for Predicting Drug Safety
Pharmacovigilance in Special Populations: Pregnant Women and Pediatrics
Drug Safety Communication: Enhancing Patient Awareness and Education
Role of Pharmacovigilance in Drug Regulatory Affairs
Pharmacovigilance Data Mining: Leveraging Big Data for Drug Safety
Pharmacovigilance Systems and Reporting Structures
Pharmacogenetic Testing in Drug Safety Assessment

This comprehensive list of pharmacology research paper topics provides a broad range of ideas and areas to explore within the field of pharmacology. From drug discovery and development to clinical pharmacology, neuropharmacology, and pharmacokinetics, each category offers multiple topics for students to delve into and contribute to the advancement of pharmacological knowledge. Whether you are interested in the impact of pharmacogenomics on drug therapy, exploring novel treatment strategies, or investigating drug safety and pharmacovigilance, there is a wealth of research possibilities awaiting exploration. By selecting a topic of interest and following the expert advice on topic selection and research paper writing, students can embark on an enriching journey of discovery and make meaningful contributions to the field of pharmacology.

Pharmacology: Exploring the Range of Research Paper Topics

Pharmacology is a captivating and dynamic scientific discipline that focuses on the study of drugs and their effects on living organisms. It plays a crucial role in improving human health by advancing our understanding of how medications interact with biological systems. Within the field of pharmacology, there is a vast array of pharmacology research paper topics that offer students an opportunity to delve into various aspects of drug discovery, development, clinical application, and safety. In this article, we will explore the breadth and depth of pharmacology as a scientific field, highlighting the range of research paper topics it encompasses.

Drug Discovery and Development: One exciting area of pharmacology research is drug discovery and development. This field involves the identification and development of new therapeutic agents to treat a wide range of diseases. Students interested in this area can explore topics such as the exploration of novel drug targets and therapeutic approaches, investigating natural products for drug development, advancements in targeted drug delivery systems, pharmacokinetics and pharmacodynamics of new drug entities, and understanding and overcoming drug resistance mechanisms.

Clinical Pharmacology: Clinical pharmacology focuses on the application of pharmacological principles in the clinical setting. It plays a vital role in optimizing drug therapy and ensuring patient safety. Pharmacology research paper topics in this area may include pharmacogenomics, which explores the relationship between an individual’s genetic makeup and their response to medication. Other topics of interest include the identification, prevention, and management of adverse drug reactions, the design and ethical considerations in clinical trials, pharmacovigilance, and optimizing drug regimens for special populations such as pediatrics, geriatrics, and pregnant women.

Neuropharmacology and Psychopharmacology: The field of neuropharmacology examines how drugs interact with the central nervous system and influence brain function. Pharmacology research paper topics in this area may involve investigating the mechanisms of action and therapeutic applications of psychotropic drugs, exploring neurotransmitter systems and their role in neurological disorders, pharmacological interventions for Alzheimer’s disease and other neurodegenerative disorders, the psychopharmacology of substance use disorders, and the pharmacological management of mental health disorders.

Pharmacokinetics and Drug Metabolism: Pharmacokinetics and drug metabolism focus on understanding how drugs are absorbed, distributed, metabolized, and eliminated by the body. Pharmacology research paper topics in this area may include studying drug interactions, such as the mechanisms, predictions, and clinical implications of drug-drug interactions. Other topics of interest include pharmacogenetics and individual variations in drug response, the role of drug transporters in drug disposition, drug metabolism and its impact on drug-drug interactions, and the use of predictive modeling in pharmacokinetics and dosing optimization.

Pharmacology of Infectious Diseases: The pharmacology of infectious diseases involves studying how drugs can effectively treat and prevent infections. Research topics in this area may include exploring antimicrobial resistance, including its mechanisms, epidemiology, and strategies to combat it. Additionally, students may investigate the development of new antiviral agents, the pharmacological management of bacterial infections, host-pathogen interactions, and the pharmacokinetic considerations in the treatment of infectious diseases.

Cardiovascular Pharmacology: Cardiovascular pharmacology focuses on understanding the effects of drugs on the cardiovascular system. Research topics in this area may include exploring drug therapy for hypertension and current guidelines for treatment, novel anticoagulants in the prevention and treatment of thromboembolic disorders, pharmacological approaches to managing heart failure, drug-induced cardiotoxicity and strategies for prevention, and emerging pharmacotherapies for atherosclerosis and coronary artery disease.

Pharmacology and Aging: Pharmacology and aging is a specialized field that investigates how drug therapy can be optimized in older adults. Research topics in this area may include exploring geriatric pharmacotherapy, age-related changes in pharmacokinetics and pharmacodynamics, the impact of polypharmacy on older adults, the recognition and prevention of adverse drug reactions, pharmacological management of age-related neurodegenerative disorders, and strategies for improving medication adherence in the elderly.

The field of pharmacology offers a wide range of exciting research paper topics that span from drug discovery and development to clinical pharmacology, neuropharmacology, pharmacokinetics, and beyond. By exploring these topics, students can contribute to the advancement of pharmacological knowledge and make meaningful contributions to the field. Remember to choose a research topic that aligns with your interests and career aspirations, and be sure to consult with your instructors or mentors for guidance throughout your research journey. With dedication, curiosity, and a passion for improving patient care, you have the opportunity to shape the future of pharmacology research.

How to Choose a Pharmacology Research Topic

Choosing the right research paper topic is crucial for a successful academic journey in pharmacology. It allows you to explore your interests, contribute to the field, and showcase your knowledge and skills. However, with the vast scope of pharmacology, selecting a research topic can be a daunting task. In this section, we will provide you with expert advice on how to choose pharmacology research paper topics that are engaging, relevant, and have the potential for significant contribution.

Identify Your Interests : Start by identifying your areas of interest within pharmacology. Reflect on the topics that have captivated your attention during your coursework or sparked your curiosity. Consider whether you are more inclined towards drug discovery, clinical applications, pharmacokinetics, neuropharmacology, or any other subfield of pharmacology. This self-reflection will help you narrow down your options and select a topic that resonates with your passion.
Stay Updated with Current Research : To choose a compelling research topic, it is essential to stay updated with the latest advancements and trends in pharmacology. Follow reputable scientific journals, attend conferences, and engage with the pharmacological community to gain insights into the ongoing research and emerging areas of interest. This will help you identify gaps in the current knowledge and select a topic that offers the potential for novel discoveries or addressing existing challenges.
Consult with Faculty and Experts : Seek guidance from your faculty members, mentors, or experts in the field of pharmacology. They can provide valuable insights and suggest potential research areas based on their expertise and experience. Discuss your interests, goals, and research aspirations with them, and they can help you refine your research topic, provide relevant literature references, and offer valuable advice on the feasibility and scope of your chosen topic.
Consider Practicality and Resources : When selecting a research topic, consider the practicality and availability of resources. Assess whether the necessary laboratory facilities, equipment, or access to clinical data are readily accessible to conduct your research. Additionally, consider the time and resources required to complete the research within the given timeframe. Choosing a topic that aligns with the available resources will enhance the feasibility and success of your research endeavor.
Address Current Challenges or Gaps : Pharmacology is a field that constantly evolves, presenting new challenges and unanswered questions. Consider selecting a research topic that addresses current challenges or explores gaps in the existing knowledge. This could involve investigating the mechanisms of drug resistance, exploring novel drug targets, or optimizing drug regimens for specific patient populations. By tackling these challenges, you can contribute to the advancement of pharmacological science and make a meaningful impact.
Collaborate with Peers : Consider collaborating with fellow students or researchers who share similar research interests. Collaborative research projects can provide a broader perspective, foster knowledge sharing, and enhance the overall quality of your research. Collaborating with peers also allows you to divide the workload, share resources, and receive feedback and support throughout the research process.
Seek Ethical Considerations : When selecting a pharmacology research topic, it is essential to consider ethical considerations and adhere to the principles of research ethics. Ensure that your chosen topic respects patient confidentiality, follows the guidelines for the ethical use of animal subjects (if applicable), and aligns with the ethical principles outlined by regulatory bodies. Consulting with your institution’s ethics committee or research advisor can help ensure that your research project meets the required ethical standards.
Evaluate Feasibility and Novelty : Evaluate the feasibility and novelty of your chosen research topic. Consider whether the research question is answerable within the available resources and time constraints. Additionally, assess whether your topic brings something new to the field, whether it fills a knowledge gap, or offers a fresh perspective on an existing topic. A balance between feasibility and novelty is essential for a successful research paper.
Consult Literature Reviews : Conduct thorough literature reviews on your chosen topic to gain a comprehensive understanding of the existing research. Literature reviews help you identify gaps in the current knowledge and provide a foundation for your research question. They also enable you to build on previous findings, develop a robust research methodology, and position your research within the context of the broader field of pharmacology.
Remain Flexible : Lastly, remain flexible throughout the process of choosing a research topic. As you delve deeper into the literature and research process, you may discover new avenues of interest or encounter unexpected challenges. It is essential to remain open to refining or adjusting your research topic based on new insights, emerging data, or feedback from your research advisors. Flexibility allows you to adapt and ensure that your research remains relevant and impactful.

Choosing a pharmacology research paper topic is an exciting and important step in your academic journey. By following expert advice, identifying your interests, staying updated with current research, seeking guidance, considering practicality and resources, addressing current challenges or gaps, collaborating with peers, adhering to ethical considerations, evaluating feasibility and novelty, consulting literature reviews, and remaining flexible, you can select a research topic that is engaging, relevant, and has the potential to contribute to the field of pharmacology. Remember, this is your opportunity to explore, innovate, and make a lasting impact in the dynamic field of pharmacology research.

How to Write a Pharmacology Research Paper

Writing a pharmacology research paper requires careful planning, organization, and attention to detail. It is an opportunity for you to showcase your understanding of the subject matter, critical thinking skills, and ability to communicate scientific information effectively. In this section, we will provide you with expert guidance on how to write a pharmacology research paper that is well-structured, informative, and compelling.

Choose a Well-Defined Research Question : Start by formulating a clear and well-defined research question. Your research question should be focused, specific, and address a gap in the existing knowledge. Consider the significance of your research question in the context of pharmacology and how it contributes to the overall understanding of the field. A well-defined research question sets the foundation for your entire research paper.
Conduct a Thorough Literature Review : Before diving into your research, conduct a thorough literature review on the chosen topic. Familiarize yourself with the existing research, theories, and findings related to your research question. This will provide you with a solid understanding of the current state of knowledge and help you identify gaps or areas for further investigation. Additionally, the literature review will inform your research methodology and discussion of results.
Develop a Clear Structure : A well-structured research paper is essential for effectively conveying your ideas and findings. Begin with an engaging introduction that provides background information, context, and clearly states your research question. Follow with a comprehensive literature review that supports your research question and highlights the gaps in knowledge. Next, present your research methodology, including details on sample selection, data collection, and analysis methods. In the results section, present your findings in a clear and organized manner using tables, graphs, or figures as necessary. Finally, discuss your results, interpret their significance, and relate them back to your research question in the discussion section. Conclude with a concise summary of your findings and their implications.
Use Reliable and Credible Sources : Ensure that the sources you use for your research paper are reliable, credible, and peer-reviewed. Consult reputable scientific journals, textbooks, and conference proceedings. Avoid relying solely on internet sources or non-scholarly publications. Citations are critical to acknowledge the work of other researchers and to support your claims and arguments. Use a consistent citation style, such as APA, MLA, or Chicago, and follow the guidelines carefully.
Analyze and Interpret Your Data : If your research involves collecting and analyzing data, ensure that your data analysis is thorough and accurate. Use appropriate statistical methods to analyze your data and present the results in a clear and meaningful way. Interpret the findings in the context of your research question and discuss any limitations or potential sources of bias. Remember to relate your findings back to the existing literature and explain how they contribute to the broader understanding of pharmacology.
Write Clearly and Concisely : Effective scientific writing is clear, concise, and free of unnecessary jargon. Use language that is precise and straightforward, avoiding ambiguous or vague statements. Clearly articulate your ideas and ensure that your arguments are logical and well-supported by evidence. Use appropriate scientific terminology, but also consider your target audience and strive to communicate your findings in a way that is accessible to readers who may not have expertise in pharmacology.
Pay Attention to Formatting and Style : Follow the formatting and style guidelines specified by your instructor or the target journal. Pay attention to details such as font size, line spacing, margins, and headings. Use subheadings to organize your content and make it easier for readers to navigate. Adhere to the specific citation style required for your paper and ensure that your references are complete and accurate.
Revise and Edit : Revision and editing are essential steps in the writing process. Take the time to review your research paper for clarity, coherence, and accuracy. Check for grammatical errors, spelling mistakes, and punctuation errors. Ensure that your ideas flow logically and that your paper is well-structured. Consider seeking feedback from peers, instructors, or mentors to gain different perspectives and improve the overall quality of your paper.
Proofread : Before submitting your research paper, thoroughly proofread it to ensure that it is error-free. Check for any typos, inconsistencies, or formatting issues. Read your paper aloud to catch any awkward phrasing or unclear sentences. It can also be helpful to have someone else read your paper to identify any errors or areas that need improvement.
Ethical Considerations : Ensure that your research paper adheres to ethical considerations. If your research involved human subjects, ensure that you have obtained the necessary approvals and informed consent. Respect patient confidentiality and anonymity when presenting your research findings. Adhere to the ethical guidelines set by your institution or the relevant regulatory bodies.

Writing a pharmacology research paper requires careful planning, thorough research, effective communication, and attention to detail. By following the expert advice provided in this section, you can develop a well-structured and informative research paper that contributes to the field of pharmacology. Remember to choose a well-defined research question, conduct a thorough literature review, use reliable sources, analyze and interpret your data, write clearly and concisely, pay attention to formatting and style, revise and edit your paper, proofread for errors, and ensure ethical considerations are met. With diligence and commitment, your pharmacology research paper has the potential to make a meaningful impact in the field of pharmacology.

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Pharmacol Res Perspect
v.11(1); 2023 Feb

Pharmacology Research & Perspectives : A Decade of Progress

Michael f. jarvis.

1 Pharmaceutical Sciences, University of Illinois at Chicago, Chicago Illinois, USA

Emily Davies

2 Wiley Blackwell, Oxford UK

Jennifer H. Martin

3 The University of Newcastle Hunter Medical Research Institute, New Lambton New South Wales, Australia

Pharmacology Research & Perspectives (PR&P) began publication in 2013 as a gold open‐access journal collaboration between the American Society for Pharmacology and Experimental Therapeutics (ASPET), the British Pharmacology Society (BPS), and Wiley. Since then, the journal has flourished in terms of increased numbers of papers submitted and published, impact factor, and downloaded content. While PR&P has always encouraged authors to directly submit their research to the journal, PR&P has also welcomed manuscript transfers. This enables authors to transfer submissions to PR&P that were originally intended for the established journals of ASPET, BPS, and other supporting biomedical and clinical research journals 1 but were determined not to be competitive enough by their respective editorial boards. This editorial approach has provided the PR&P readership and authors access to rigorous research advances covering both basic and clinical pharmacology in the context of further enabling research reliability and reproducibility, fostering the early clinical development of new chemical entities, and challenging existing pharmacological dogma. PR&P has consistently maintained an author‐focused approach to editorial content and the editorial board encourages submissions of original research, short reports, reviews, and topical perspectives that address key issues in pharmacology. Prospective authors are encouraged to carefully review the PR&P Author Guidelines when preparing manuscripts for submission, as they are routinely updated with the latest publishing practices and requirements. 2

In 2019, PR&P received its first Impact Factor (2.05), and this metric has steadily increased to 2.97 for 2022. Using 2019 as a benchmark, submissions to PR&P have increased between 200–300% in the succeeding two years. The number of papers published have also significantly increased (50–100%) over this time. Consequently, the acceptance rate for publication in PR&P has decreased to approximately 30% of submitted papers as the editorial board has continued its work to further build the scientific quality of the journal. Authors should be aware that the acceptance rate for transferred papers from supporting journals is typically higher. In all cases, transferred papers accepted by PR&P communicate rigorous science that is well within the scope of PR&P's strategic goals and authors have effectively resolved the original peer review feedback they have received. In response to the continued growth of the journal, PR&P has also recently established a group of Senior Editors representing the diversity of pharmacology interests across the globe to oversee peer‐review and ensure authors continue to receive timely and constructive critiques of their manuscripts.

Improving the author's experience is central to the PR&P strategy. Over the past few years the journal has implemented new workflows and processes to reduce the post‐acceptance time to publication to an average of 23 days for 2022. While the time to first decision is already very competitive, at an average of just four days for 2022, PR&P will continue to prioritize decreasing the time to final decision with the help of the newly established Senior Editors. The journal also aims to reduce time spent by authors on the initial submission process, by introducing a new author facing submission platform, Research Exchange 3 which has already been piloted and rolled out across over 400 Wiley journals. To further reduce author time spent resubmitting manuscripts, and to reduce reviewer demand, PR&P will continue to support transfer networks between journals, inclusive of expanding this network to offer referral options to papers deemed out of scope for PR&P .

Since its inception, PR&P has actively encouraged submission of papers that address all aspects of drug action including new hypotheses, mechanisms of action, target identification, target validation, lead optimization, and clinical development including translational medicine, quality use of medicines projects, drug repurposing studies, and pharmacovigilance. Another major focus has also been on the enhancement of research reliability through the publication of replication studies and negative results from well‐designed experimental research projects. Over the last several years, PR&P has provided readers with multiple dedicated issues that cover these and other cutting‐edge pharmacological research topics (Table 1 ). Of particular importance to the strategic goals of PR&P is highlighting research contributions from different geographical regions and providing a venue for early career researchers to submit original research and topical reviews that are based on their graduate and/or post‐doctoral experiences. PR&P has also partnered with other BPS journals to generate special virtual issues in the areas of sex as an independent variable and COVID‐19 research. More recently, PR&P has championed the publication of advances in pharmacology education including new instructional models, curricula, and best practices. Readers are encouraged to access the recently published BPS statement on Inclusive Pharmacology Education. 4

Selected Themed/Special Issues of Pharmacology Research & Perspectives .

March 2022 November 2021 October 2021 January 2020 December 2020 October 2020 July 2020 March 2020

Going forward, PR&P will continue to build upon the strategic initiatives noted above. Readers can expect new thematic issues highlighting pharmacology research from the African Continent, a special issue on Pharmacology Education and Innovation, and further efforts to advance research generated by early career scientists. To assist potential authors in considering new submissions to PR&P , please see the thematic tips outlined in Table 2 . Prospective authors are also encouraged to contact PR&P regarding special projects such as key scientific meeting summaries, risk/benefit profiles for new drug classes, or new technological advances that advance understanding of drug mechanisms.

PR&P Thematic Priorities for Potential Authors.

encourages submissions covering the general topics below

Papers that are out of scope for

40+ Pharmacology Research Topics: A Comprehensive Guide for Nursing Students

Understanding pharmacology is crucial for nursing students as it forms the foundation of safe and effective patient care. This article aims to give nursing students insights into pharmacology research topics and potential research directions.

What You'll Learn

The Importance of Pharmacology in Nursing Education

Pharmacology involves studying how drugs interact with living organisms, including their effects, mechanisms, and possible side effects. Pharmacology knowledge is essential for administering medications, understanding drug interactions, and ensuring patient safety . By grasping pharmacological principles, nursing students can make informed decisions and deliver evidence-based care.

Exploring PICOT Questions in Pharmacology

P: Adult psychiatric patients; I: Daily RS questionnaire; C: Units without daily survey; O: Reduced RS utilization; T: 6 months. Compared to units without the survey, can introducing a daily RS (Recovery Scale) questionnaire in psychiatric units lead to significantly decreased RS utilization over six months?
P: Pediatric asthma patients; I: Peak flow monitoring; C: Standard symptom-based management; O: Decreased severe asthma exacerbations; T: 1 year. Does incorporating peak flow monitoring for pediatric asthma patients result in significantly fewer severe asthma exacerbations over a year compared to standard management?
P: Elderly long-term care residents; I: Structured medication reconciliation; C: Informal reconciliation; O: Reduced medication discrepancies; T: 3 months. Among elderly in long-term care, does implementing structured medication reconciliation lead to significantly fewer medication discrepancies within three months compared to informal methods?
P: Postoperative patients; I: Multimodal pain management ; C: Traditional pain management; O: Reduced opioid consumption; T: Postoperative period. Can adopting a multimodal pain management approach significantly reduce opioid consumption in postoperative patients compared to traditional methods?
P: Diabetic patients; I: Interactive technology education; C: Conventional education; O: Improved glycemic control; T: 6 months. Among diabetic patients, does interactive technology education lead to better glycemic control over six months compared to conventional education?
P: Oncology patients on chemotherapy ; I: Pre-chemotherapy antiemetic; C: Post-chemotherapy antiemetic; O: Reduced chemotherapy-induced nausea and vomiting; T: During chemotherapy. For oncology patients undergoing chemotherapy, does administering antiemetics before chemotherapy significantly decrease chemotherapy-induced nausea and vomiting compared to post-chemotherapy administration?
P: Hypertensive patients; I: Home blood pressure monitoring; C: Clinic-based monitoring; O: Improved blood pressure control; T: 3 months. Does home blood pressure monitoring lead to better blood pressure control in hypertensive patients over three months compared to clinic-based monitoring?
P: Critically ill ventilated patients; I: Early mobilization; C: Delayed mobilization; O: Shorter mechanical ventilation; T: ICU stay. Among critically ill ventilated patients, does early mobilization lead to shorter mechanical ventilation durations during ICU stays compared to delayed mobilization?
P: Chronic pain patients; I: Mindfulness program; C: Standard pain management; O: Improved pain relief, quality of life; T: 8 weeks. Can participating in a mindfulness program lead to better pain relief and quality of life for chronic pain patients over eight weeks compared to standard pain management?
P: Postmenopausal women; I: Calcium, vitamin D supplementation; C: No supplementation; O: Decreased bone density loss; T: 1 year. Among postmenopausal women at risk of osteoporosis, does calcium, vitamin D supplementation significantly reduce bone density loss over a year compared to no supplementation?

Evidence-Based Practice (EBP) Projects in Pharmacology

Analyzing medication reconciliation’s impact on adverse drug events in geriatric patients.
Comparing patient-controlled analgesia and nurse-controlled analgesia in postoperative pain management.
Studying medication adherence’s effect on glycemic control in diabetes patients.
Investigating antipsychotic medication use and fall risk in elderly psychiatric patients.
Assessing pharmacogenomic testing’s role in psychiatric medication personalization.
Comparing antiemetic agents for chemotherapy-induced nausea and vomiting prevention.
Evaluating a structured pain assessment tool’s impact on pediatric pain management.
Examining home blood pressure monitoring’s effect on hypertension control .
Investigating opioid-sparing techniques in orthopedic postoperative pain management.
Exploring herbal supplement use for managing menopausal symptoms.

Nursing Capstone Project Ideas in Pharmacology

Designing a comprehensive medication education program for pediatric patients and caregivers.
Developing a protocol for high-alert medication administration in critical care units.
Creating a chronic pain interdisciplinary management plan in long-term care.
Implementing a medication safety campaign to reduce errors in emergency departments.
Designing a rural telehealth platform for medication counseling and adherence.
Establishing immunosuppressive medication adverse reaction monitoring post-transplant.
Creating a guideline for nurses in helping patients optimize polypharmacy.
Designing a chemotherapy administration and monitoring training module.
Developing a vasopressor medication titration protocol for septic shock.
Creating a herbal supplement interaction resource guide.

Research Paper Topics in Pharmacology for Nursing Students

Pharmacogenomics’ role in personalizing psychiatric medication regimens.
Nurse contributions to preventing opioid misuse and overdose in the epidemic.
Evaluating cultural diversity’s impact on medication beliefs and adherence.
Strategies for optimizing medication regimens and preventing adverse effects in the elderly.
Pharmacovigilance’s importance in monitoring and reporting adverse drug reactions.
Herbal supplement-drug interaction evidence and practice analysis.
Ethical considerations in pediatric medication administration.
Antibiotic resistance’s implications and nurses’ role in prudent antibiotic use.
Addressing medication disparities in healthcare.
Medication errors: Causes, consequences, and prevention in nursing practice.

Understanding pharmacology is paramount for nursing students’ ability to provide safe and effective patient care. With knowledge of pharmacology, nursing students can make informed decisions and contribute to healthcare. Explore PICOT questions, research projects, and essay topics to enhance learning and engage in impactful healthcare practices. For further assistance, consider our writing services tailored to nursing students’ needs, helping you merge pharmacological knowledge with effective communication to excel in healthcare.

FAQs about Pharmacology in Nursing

Q: What is pharmacology in nursing?

A: Pharmacology in nursing studies how drugs interact with living organisms, encompassing their effects, mechanisms, and potential side effects. It’s a crucial field for nurses to ensure safe and effective patient care through proper medication administration and management.

Q: What are the 5 importance of pharmacology in nursing?

A: The importance of pharmacology in nursing includes enabling nurses to understand drug interactions, administer medications safely, manage patient responses, prevent adverse reactions, and provide evidence-based care.

Q: What are the principles of pharmacology for nurses?

A: The principles of pharmacology for nurses involve understanding drug actions, indications, contraindications, interactions, and adverse effects. It also includes proper dosage calculation, patient education , and ethical considerations.

Q: What are the types of pharmacology?

A: Pharmacology can be broadly categorized into several types, including clinical pharmacology (study of drugs in clinical settings), neuropharmacology (study of drugs affecting the nervous system), and psychopharmacology (study of drugs for mental disorders). Additionally, there’s pharmacokinetics (drug absorption, distribution, metabolism, excretion) and pharmacodynamics (drug effects on the body).

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We collate information related to SARS-CoV-2 and COVID-19 on a dedicated coronavirus information page . This contains details of ligands and targets relevant to COVID-19 and links to useful resources and publications.

Recent publications of interest recommended by NC-IUPHAR

2024: sep | aug | jul | jun | may | apr | mar | jan 2023: nov | oct, september 2024.

Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40. Tong Y, Childs-Disney JL, Disney MD. Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40. (2024) Br J Pharmacol , [Epub ahead of print]. [PMID: 39224931 ]

August 2024

A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W et al. . A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. (2024) Nat Commun , 15 (1): 6643. [PMID: 39103320 ]
Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor. Matarage Don NNJ, Padmavathi R, Khasro TD, Zaman MRU, Ji HF, Ram JL, Ahn YH. Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor. (2024) ACS Chem Biol , 19 (7): 1661-1670. [PMID: 38975966 ]
Cryo-EM Structure and Biochemical Analysis of the Human Chemokine Receptor CCR8. Peng Q, Jiang H, Cheng X, Wang N, Zhou S, Zhang Y, Yang T, Chen Y, Zhang W, Lv S et al. . Cryo-EM Structure and Biochemical Analysis of the Human Chemokine Receptor CCR8. (2024) Biochemistry , [Epub ahead of print]. [PMID: 38985857 ]
ChemFREE: a one-stop comprehensive platform for ecological and environmental risk evaluation of chemicals in one health world. Chen D, Liu Y, Liu Y, Zhao K, Zhang T, Gao Y, Wang Q, Song B, Hao G. ChemFREE: a one-stop comprehensive platform for ecological and environmental risk evaluation of chemicals in one health world. (2024) Nucleic Acids Res , 52 (W1): W450-W460. [PMID: 38832633 ]
The cerebellum modulates thirst. Mishra I, Feng B, Basu B, Brown AM, Kim LH, Lin T, Raza MA, Moore A, Hahn A, Bailey S et al. . The cerebellum modulates thirst. (2024) Nat Neurosci , [Epub ahead of print]. [PMID: 38987435 ]
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid. Zhou T, Cheng J, He S, Zhang C, Gao MX, Zhang LJ, Sun JP, Zhu Y, Ai D. The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid. (2024) Nat Metab , [Epub ahead of print]. [PMID: 38907081 ]
Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption. Fu Y, Mackowiak B, Lin YH, Maccioni L, Lehner T, Pan H, Guan Y, Godlewski G, Lu H, Chen C et al. . Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption. (2024) Nat Metab , [Epub ahead of print]. [PMID: 38902331 ]
Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation. He N, Depta L, Rossetti C, Caramelle L, Cigler M, Bryce-Rogers HP, Michon M, Rafn Dan O, Hoock J, Barbier J et al. . Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation. (2024) Nat Chem Biol , [Epub ahead of print]. [PMID: 38907112 ]
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP. Cigler M, Imrichova H, Frommelt F, Caramelle L, Depta L, Rukavina A, Kagiou C, Hannich JT, Mayor-Ruiz C, Superti-Furga G et al. . Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP. (2024) Nat Chem Biol , [Epub ahead of print]. [PMID: 38907113 ]
3-Hydroxykynurenine targets kainate receptors to promote defense against infection. Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW et al. . 3-Hydroxykynurenine targets kainate receptors to promote defense against infection. (2024) Nat Chem Biol , [Epub ahead of print]. [PMID: 38898166 ]
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. Ting PY, Borikar S, Kerrigan JR, Thomsen NM, Aghania E, Hinman AE, Reyes A, Pizzato N, Fodor BD, Wu F et al. . A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction. (2024) Science , 385 (6704): 91-99. [PMID: 38963839 ]
NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. Dahl K, Raun K, Hansen JL, Poulsen C, de la Cour CD, Clausen TR, Hansen AMK, John LM, Plesner A, Sun G et al. . NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin. (2024) J Med Chem , [Epub ahead of print]. [PMID: 38960379 ]
A µ-opioid receptor modulator that works cooperatively with naloxone. O'Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q et al. . A µ-opioid receptor modulator that works cooperatively with naloxone. (2024) Nature , [Epub ahead of print]. [PMID: 38961287 ]
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes. Kizilkaya HS, Sørensen KV, Madsen JS, Lindquist P, Douros JD, Bork-Jensen J, Berghella A, Gerlach PA, Gasbjerg LS, Mokrosiński J et al. . Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes. (2024) Nat Metab , [Epub ahead of print]. [PMID: 38871982 ]
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. Lu D, He A, Tan M, Mrad M, El Daibani A, Hu D, Liu X, Kleiboeker B, Che T, Hsu FF et al. . Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling. (2024) Nat Commun , 15 (1): 4214. [PMID: 38760332 ]
The state of the art in secondary pharmacology and its impact on the safety of new medicines. Brennan RJ, Jenkinson S, Brown A, Delaunois A, Dumotier B, Pannirselvam M, Rao M, Ribeiro LR, Schmidt F, Sibony A et al. . The state of the art in secondary pharmacology and its impact on the safety of new medicines. (2024) Nat Rev Drug Discov , [Epub ahead of print]. [PMID: 38773351 ]
Molecular mechanism of choline and ethanolamine transport in humans. Ri K, Weng TH, Claveras Cabezudo A, Jösting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G et al. . Molecular mechanism of choline and ethanolamine transport in humans. (2024) Nature , [Epub ahead of print]. [PMID: 38778100 ]
Kainate receptor channel opening and gating mechanism. Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI. Kainate receptor channel opening and gating mechanism. (2024) Nature , [Epub ahead of print]. [PMID: 38778115 ]
Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement. Chaudun F, Python L, Liu Y, Hiver A, Cand J, Kieffer BL, Valjent E, Lüscher C. Distinct µ-opioid ensembles trigger positive and negative fentanyl reinforcement. (2024) Nature , [Epub ahead of print]. [PMID: 38778097 ]
Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J et al. . Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. (2024) Nature , [Epub ahead of print]. [PMID: 38776963 ]
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice. Yun C, Yan S, Liao B, Ding Y, Qi X, Zhao M, Wang K, Zhuo Y, Nie Q, Ye C et al. . The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice. (2024) Nat Metab , [Epub ahead of print]. [PMID: 38769396 ]
Structural and functional evidence that GPR30 is not a direct estrogen receptor. Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D et al. . Structural and functional evidence that GPR30 is not a direct estrogen receptor. (2024) Cell Res , [Epub ahead of print]. [PMID: 38744981 ]
Atypical chemokine receptors in the immune system. Comerford I, McColl SR. Atypical chemokine receptors in the immune system. (2024) Nat Rev Immunol , [Epub ahead of print]. [PMID: 38714818 ]
GLP-1-directed NMDA receptor antagonism for obesity treatment. Petersen J, Ludwig MQ, Juozaityte V, Ranea-Robles P, Svendsen C, Hwang E, Kristensen AW, Fadahunsi N, Lund J, Breum AW et al. . GLP-1-directed NMDA receptor antagonism for obesity treatment. (2024) Nature , [Epub ahead of print]. [PMID: 38750368 ]
Differential G protein activation by the long and short isoforms of the dopamine D 2 receptor. Reiner-Link D, Madsen JS, Gloriam DE, Bräuner-Osborne H, Hauser AS. Differential G protein activation by the long and short isoforms of the dopamine D 2 receptor. (2024) Br J Pharmacol , [Epub ahead of print]. [PMID: 38725357 ]
Shifting our perspective on orphan G protein-coupled receptors. Smith NJ, Murray F. Shifting our perspective on orphan G protein-coupled receptors. (2024) Nat Struct Mol Biol , [Epub ahead of print]. [PMID: 38565695 ]
AI is a viable alternative to high throughput screening: a 318-target study. Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. (2024) Sci Rep , 14 (1): 7526. [PMID: 38565852 ]
MFSD7c functions as a transporter of choline at the blood-brain barrier. Nguyen XTA, Le TNU, Nguyen TQ, Thi Thuy Ha H, Artati A, Leong NCP, Nguyen DT, Lim PY, Susanto AV, Huang Q et al. . MFSD7c functions as a transporter of choline at the blood-brain barrier. (2024) Cell Res , 34 (3): 245-257. [PMID: 38302740 ]
Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport. Boytsov D, Madej GM, Horn G, Blaha N, Köcher T, Sitte HH, Siekhaus D, Ziegler C, Sandtner W, Roblek M. Orphan lysosomal solute carrier MFSD1 facilitates highly selective dipeptide transport. (2024) Proc Natl Acad Sci U S A , 121 (13): e2319686121. [PMID: 38507452 ]
Activation of GPR81 by lactate drives tumour-induced cachexia. Liu X, Li S, Cui Q, Guo B, Ding W, Liu J, Quan L, Li X, Xie P, Jin L et al. . Activation of GPR81 by lactate drives tumour-induced cachexia. (2024) Nat Metab , [Epub ahead of print]. [PMID: 38499763 ]
The kainate receptor GluK2 mediates cold sensing in mice. Cai W, Zhang W, Zheng Q, Hor CC, Pan T, Fatima M, Dong X, Duan B, Xu XZS. The kainate receptor GluK2 mediates cold sensing in mice. (2024) Nat Neurosci , [Epub ahead of print]. [PMID: 38467901 ]
An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure. Xu J, Choi R, Gupta K, Warren HR, Santhanam L, Pluznick JL. An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure. (2024) Sci Adv , 10 (12): eadk1487. [PMID: 38507492 ]
Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data. Weissgerber TL, Gazda MA, Nilsonne G, Ter Riet G, Cobey KD, Prieß-Buchheit J, Noro J, Schulz R, Tijdink JK, Bobrov E et al. . Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data. (2024) Nat Med , [Epub ahead of print]. [PMID: 38514869 ]
Promoting gender equity in the scientific and health workforce is essential to improve women's health. Vieira Machado C, Araripe Ferreira C, de Souza Mendes Gomes MA. Promoting gender equity in the scientific and health workforce is essential to improve women's health. (2024) Nat Med , [Epub ahead of print]. [PMID: 38519768 ]

January 2024

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. Cervia-Hasler C, Brüningk SC, Hoch T, Fan B, Muzio G, Thompson RC, Ceglarek L, Meledin R, Westermann P, Emmenegger M et al. . Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. (2024) Science , 383 (6680): eadg7942. [PMID: 38236961 ]
EPAC1 enhances brown fat growth and beige adipogenesis. Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc'h F, Krahmer N, Pfeifer A. EPAC1 enhances brown fat growth and beige adipogenesis. (2024) Nat Cell Biol , 26 (1): 113-123. [PMID: 38195707 ]
Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. Chiu TY, Lazar DC, Wang WW, Wozniak JM, Jadhav AM, Li W, Gazaniga N, Theofilopoulos AN, Teijaro JR, Parker CG. Chemoproteomic development of SLC15A4 inhibitors with anti-inflammatory activity. (2024) Nat Chem Biol , [Epub ahead of print]. [PMID: 38191941 ]
Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. Sosinsky A, Ambrose J, Cross W, Turnbull C, Henderson S, Jones L, Hamblin A, Arumugam P, Chan G, Chubb D et al. . Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme. (2024) Nat Med , 30 (1): 279-289. [PMID: 38200255 ]
Structural basis of prostaglandin efflux by MRP4. Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL et al. . Structural basis of prostaglandin efflux by MRP4. (2024) Nat Struct Mol Biol , [Epub ahead of print]. [PMID: 38216659 ]
Biased agonists of GPR84 and insights into biological control. Luscombe VB, Wang P, Russell AJ, Greaves DR. Biased agonists of GPR84 and insights into biological control. (2023) Br J Pharmacol , [Epub ahead of print]. [PMID: 38148720 ]

November 2023

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Boby ML, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson MC, COVID Moonshot Consortium‡, Chodera JD, Lee AA, London N et al. . Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. (2023) Science , 382 (6671): eabo7201. [PMID: 37943932 ]

October 2023

The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Harding SD, Armstrong JF, Faccenda E, Southan C, Alexander SPH, Davenport AP, Spedding M, Davies JA. The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. (2024) Nucleic Acids Res , 52 (D1): D1438-D1449. [PMID: 37897341 ]
ADCdb: the database of antibody-drug conjugates. Shen L, Sun X, Chen Z, Guo Y, Shen Z, Song Y, Xin W, Ding H, Ma X, Xu W et al. . ADCdb: the database of antibody-drug conjugates. (2024) Nucleic Acids Res , 52 (D1): D1097-D1109. [PMID: 37831118 ]
TTD: Therapeutic Target Database describing target druggability information. Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F. TTD: Therapeutic Target Database describing target druggability information. (2024) Nucleic Acids Res , 52 (D1): D1465-D1477. [PMID: 37713619 ]
Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW et al. . Functional screening and rational design of compounds targeting GPR132 to treat diabetes. (2023) Nat Metab , 5 (10): 1726-1746. [PMID: 37770763 ]
Genome-wide association analysis reveals insights into the molecular etiology underlying dilated cardiomyopathy. Zheng SL, Henry A, Cannie D, Lee M, Miller D, McGurk KA, Bond I, Xu X, Issa H, Francis C et al. . Genome-wide association analysis reveals insights into the molecular etiology underlying dilated cardiomyopathy. (2023) medRxiv , Preprint. DOI: https://www.medrxiv.org/content/10.1101/2023.09.28.23295408v1
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Lees JA, Dias JM, Rajamohan F, Fortin JP, O'Connor R, Kong JX, Hughes EAG, Fisher EL, Tuttle JB, Lovett G et al. . An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. (2023) Nat Commun , 14 (1): 5938. [PMID: 37741852 ]
Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P et al. . Cryo-EM structures of human GPR34 enable the identification of selective antagonists. (2023) Proc Natl Acad Sci U S A , 120 (39): e2308435120. [PMID: 37733739 ]

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