thesis on prostate cancer

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Improving The Diagnosis And Risk Stratification Of Prostate Cancer

The current diagnostic and stratification pathway for prostate cancer has led to over-diagnosis and over- treatment. This thesis aims to improve the prostate cancer diagnosis pathway by developing a minimally invasive blood test to inform diagnosis alongside mpMRI and to understand the true Gleason 4 burden which will help better stratify disease and guide clinicians in treatment planning. To reduce the number of patients who have to undergo prostate biopsy after indeterminate or false positive prostate mpMRI, we aimed to develop a new panel of mRNA detectable in blood or urine that was able to improve the detection of clinical significant prostate cancer (Gleason 4+3 or ≥6mm) in combination with prostate mpMRI. mRNA expression of 28 potential genes was studied in four prostate cancer cell lines and, using publicly available datasets, a new seven gene biomarker panel was developed using machine learning techniques. The signature was then validated in blood and urine samples from the ProMPT, PROMIS and INNOVATE trials. To redefine the classification of Gleason 4 disease in prostate cancer patients, digital pathology was used to contour and accurately assess the burden and spread of Gleason 4 in a cohort of PROMIS patients compared to the gold standard manual pathology. There was a significant difference between observed and objective Gleason 4 burden that has implications in patient risk stratification and biomarker discovery. The work presented in this thesis makes a significant step toward improving the patient diagnostic and risk classification pathways by ensuring only the right patients are biopsied when necessary, improving the current pathological reference standard.

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Welcome to Prostate Cancer and Prostatic Diseases

Germline and somatic testing for homologous repair deficiency in patients with prostate cancer (part 1 of 2)

• Andrew J. Armstrong
• Joshua M. Lang

Salvage therapies for biochemical recurrence after definitive local treatment: a systematic review, meta-analysis, and network meta-analysis

• Akihiro Matsukawa
• Takafumi Yanagisawa
• Pawel Rajwa

Cardiovascular events among men with prostate cancer treated with androgen receptor signaling inhibitors: a systematic review, meta-analysis, and network meta-analysis

• Shahrokh F. Shariat

Impact of a rash management guide in patients receiving apalutamide for high-risk localized prostate cancer in the Apa-RP study

• Jason Hafron
• Tracy McGowan

Current issue

The state of focal therapy in the treatment of prostate cancer: the university of california collaborative (uc-squared) consensus statement.

• Juan Javier-DesLoges
• Marc A. Dall’Era
• Matthew R. Cooperberg

“Quality: a parallel priority to quantity in prostate cancer focal therapy”

• Mahdi Mottaghi
• Sriram Deivasigamani
• Thomas J. Polascik

Applying prediction models in clinical practice: the importance of fine details

• Bangwei Fang

Guidelines for genetic testing in prostate cancer: a scoping review

• Haitham Tuffaha
• Kim Edmunds
• Paul Scuffham

Prognostic value of a baseline prognostic nutritional index for patients with prostate cancer: a systematic review and meta-analysis

• Shangqing Ren

Functional outcomes and safety of focal therapy for prostate cancer: a systematic review on results and patient-reported outcome measures (PROMs)

• Rossella Nicoletti
• Andrea Alberti
• Jeremy Yuen Chun Teoh

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NEW COLLECTION: LUTS and BPH management

“The times have changed. Let the urologists change!” - Our latest collection features articles covering the new and exciting field of the minimally invasive surgical techniques for benign prostatic hyperplasia and lower urinary tract symptoms.

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Emerging Leaders in Prostate Cancer

This collection features the latest research from groundbreaking researchers, clinicians, and educators who are still in the early stages of their scientific careers.

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